Rational design of a ratiometric two-photon fluorescent probe for real-time visualization of apoptosis

被引：40

作者：

Huang, Yinliang ^{[1
]}

Zhou, Qin ^{[2
]}

Feng, Yan ^{[1
]}

Zhang, Wan ^{[1
]}

Fang, Guoshun ^{[1
]}

Fang, Min ^{[1
]}

Chen, Man ^{[1
]}

Xu, Changzhi ^{[2
]}

Meng, Xiangming ^{[1
,3
]}

机构：

[1] Anhui Univ, Sch Chem & Chem Engn, Ctr Atom Engn Adv Mat, Anhui Prov Key Lab Chem Inorgan Organ Hybrid Func, Hefei 230601, Anhui, Peoples R China

[2] Anhui Univ, Inst Hlth Sci, Hefei 230601, Anhui, Peoples R China

[3] Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Anhui, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 74期

关键词：

LIVING CELLS; IN-VIVO; SELECTIVE DETECTION; METAL NANOCLUSTERS; CYSTEINE DETECTION; OXIDATIVE STRESS; MITOCHONDRIA; HOMOCYSTEINE; GLUTATHIONE; AUTOPHAGY;

D O I：

10.1039/c8cc05594g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A dialdehyde-functionalized ratiometric two-photon fluorescent probe (Mito-DCHO) based on a symmetric carbazole-containing two-dimensional ICT system was rationally designed for cysteine-specific detection in mitochondria, which was utilized for real-time assessing and dual-channel visualization of the early stage of apoptosis by monitoring mitochondrial oxidative stress levels.

引用

页码：10495 / 10498

页数：4

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