Synthesis of commercial phosphodiesterase(V) inhibitors

被引：63

作者：

Dunn, PJ ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Chem Res & Dev, Sandwich CT13 9NJ, Kent, England

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2005年 / 9卷 / 01期

关键词：

D O I：

10.1021/op040019c

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The literature syntheses (including patents) of three commercial phosphodiesterase(V) (PDE5) inhibitors (sildenafil, vardenaril, and tadalafil) are reviewed with particular emphasis on large-scale manufacture. For each of these compounds, some impressive chemical development work has been reported.

引用

页码：88 / 97

页数：10

共 49 条

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