Current status of acute hepatitis C

被引：3

作者：

Martinez-Rebollar, Maria ^{[1
]}

Larrousse, Maria ^{[1
]}

Calvo, Marta ^{[1
]}

Munoz, Ana ^{[1
]}

Gonzalez, Ana ^{[1
]}

Lonca, Montse ^{[1
]}

Martinez, Esteban ^{[1
]}

Luis Blanco, Jose ^{[1
]}

Mallolas, Josep ^{[1
]}

Laguno, Montserrat ^{[1
]}

机构：

[1] Hosp Clin Barcelona, Serv Infecc, Barcelona, Spain

来源：

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA | 2011年 / 29卷 / 03期

关键词：

Acute hepatitis C; Epidemiology; Clinical features; Diagnosis and treatment; HUMAN-IMMUNODEFICIENCY-VIRUS; INTERFERON-ALPHA THERAPY; HIV-POSITIVE MEN; T-CELL RESPONSE; SUSTAINED VIROLOGICAL RESPONSE; SPONTANEOUS VIRAL CLEARANCE; INFECTED MEN; PEGYLATED INTERFERON-ALPHA-2B; MEDICAL PROCEDURES; HCV INFECTION;

D O I：

10.1016/j.eimc.2010.12.005

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Acute hepatitis C (AHC) is an increasing health issue. Despite the decline of blood-to-blood transmission of hepatitis C virus (HCV) through donor screening programs and a decline in intravenous drug use, the incidence of sexual transmission has now increased, particularly in HIV-infected homosexual patients. The presentation is almost always asymptomatic, which complicates diagnosis. Spontaneous clearance of the virus occurs in 25% of cases and usually, within the first three months after onset of symptoms and in symptomatic patients. If serum HCV-RNA remains detectable after this period, antiviral treatment should be started without delay, since sustained viral response rate in the acute phase is higher than that achieved with chronic liver disease. The optimal treatment regimen (interferon alone or combined with ribavirin) and its duration are not clearly established at the present time. (C) 2010 Elsevier Espana, S.L. All rights reserved.

引用

页码：210 / 215

页数：6

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