REVIEW OF RECENT PROTEOMIC APPLICATIONS IN AQUATIC TOXICOLOGY

被引：75

作者：

Sanchez, Brian C. ^{[2
]}

Ralston-Hooper, Kimberly ^{[3
]}

Sepulveda, Maria S. ^{[1
]}

机构：

[1] Purdue Univ, W Lafayette, IN 47907 USA

[2] US Fish & Wildlife Serv, Lakewood, CO USA

[3] US EPA, Ecosyst Res Div, Athens, GA USA

来源：

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY | 2011年 / 30卷 / 02期

关键词：

Proteomics; Aquatic toxicology; Fish; Aquatic invertebrates; MUSSEL MYTILUS-EDULIS; PROTEIN EXPRESSION SIGNATURES; BIOMARKER DISCOVERY; MASS-SPECTROMETRY; OXIDATIVE-STRESS; RISK-ASSESSMENT; MICROCYSTIN-LR; PROFILES; IDENTIFICATION; CARBONYLATION;

D O I：

10.1002/etc.402

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Over the last decade, the environmental sciences have witnessed an incredible movement towards the utilization of high-throughput molecular tools that are capable of detecting simultaneous changes of hundreds, and even thousands, of molecules and molecular components after exposure of organisms to different environmental stressors. These techniques have received a great deal of attention because they not only offer the potential to unravel novel mechanisms of physiological and toxic action but are also amenable to the discovery of biomarkers of exposure and effects. In this article, we review the state of knowledge of one of these tools in ecotoxicological research: proteomics. We summarize the state of proteomics research in fish, and follow with studies conducted with aquatic invertebrates. A brief discussion on proteomic methods is also presented. We conclude with some ideas for future proteomic studies with fish and aquatic invertebrates. Environ. Toxicol. Chem. 2011;30:274-282. (C) 2010 SETAC

引用

页码：274 / 282

页数：9

共 80 条

[1] Proteomic analyses indicate induction of hepatic carbonyl reductase/20β-hydroxysteroid dehydrogenase B in rainbow trout exposed to sewage effluent [J].