Alpinumisoflavone inhibits osteoclast differentiation and exerts anti-osteoporotic effect in ovariectomized mice

被引：8

作者：

Cong, Wei ^{[1
]}

Zhou, Chao ^{[1
]}

Yin, Jun ^{[1
]}

机构：

[1] Shandong Univ, Qilu Hosp, Qingdao, Shandong, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2017年 / 93卷

关键词：

Alpinumisoflavone Ovariectomy-induced bone loss; c-Fos; NFATc1; ERYTHRINA-LYSISTEMON FABACEAE; BONE-RESORPTION; OSTEOBLAST DIFFERENTIATION; KAPPA-B; NATURAL-PRODUCTS; ACTIVATION; CELLS; PROLIFERATION; MECHANISMS; FLAVONOIDS;

D O I：

10.1016/j.biopha.2017.06.059

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Alpinumisoflavone (AIF), a naturally occurring flavonoid compound exacted from Derris eriocarpa, has been found to have a number of pharmacological activities. However, its role in bone disorder has not been investigated. The aim of this study is to evaluate the osteoprotective effect of AIF on ovariectomy-induced bone loss in mice model and related underlying mechanisms. Our study provides experimental evidence that AIF could regulate the remodeling process of bone and exert osteoprotective effect against ovariectomy-induced bone loss. Moreover, our results show that AIF suppresses osteoclast differentiation by attenuating RANKL-induced activation of p38, ERK and JNK pathways and consequently represses the expression of c-Fos and NFATc1. (C) 2017 Elsevier Masson SAS. All rights reserved.

引用

页码：344 / 351

页数：8

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