Erythrocytes identify complement activation in patients with COVID-19

被引：30

作者：

Lam, L. K. Metthew ^{[1
,2
]}

Reilly, John P. ^{[1
,2
]}

Rux, Ann H. ^{[3
]}

Murphy, Sophia J. ^{[1
]}

Kuri-Cervantes, Leticia ^{[4
,5
]}

Weisman, Ariel R. ^{[1
]}

Ittner, Caroline A. G. ^{[1
]}

Pampena, M. Betina ^{[4
,5
]}

Betts, Michael R. ^{[4
,5
]}

Wherry, E. John ^{[5
,6
,7
]}

Song, Wen-Chao ^{[5
,6
]}

Lambris, John D. ^{[3
]}

Meyer, Nuala J. ^{[1
,2
,5
,8
]}

Cines, Douglas B. ^{[2
,3
,5
]}

Mangalmurti, Nilam S. ^{[1
,2
,5
,8
]}

机构：

[1] Univ Penn, Div Pulm Allergy & Crit Care, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

[4] Univ Penn, Dept Microbiol, Perelman Sch Med, Philadelphia, PA 19104 USA

[5] Univ Penn, Penn Inst Immunol, Perelman Sch Med, Philadelphia, PA 19104 USA

[6] Univ Penn, Dept Syst Pharmacol & Translat Therapeut, Perelman Sch Med, Philadelphia, PA 19104 USA

[7] Univ Penn, Parker Inst Canc Immunotherapy, Philadelphia, PA 19104 USA

[8] Univ Penn, Perelman Sch Med, Lung Biol Inst, Philadelphia, PA 19104 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | 2021年 / 321卷 / 02期

基金：

美国国家卫生研究院;

关键词：

complement; COVID-19; erythrocyte; SARS-CoV-2; sepsis;

D O I：

10.1152/ajplung.00231.2021

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

COVID-19, the disease caused by the SARS-CoV-2 virus, can progress to multisystem organ failure and viral sepsis characterized by respiratory failure, arrhythmias, thromboembolic complications, and shock with high mortality. Autopsy and preclinical evidence implicate aberrant complement activation in endothelial injury and organ failure. Erythrocytes express complement receptors and are capable of binding immune complexes; therefore, we investigated complement activation in patients with COVID-19 using erythrocytes as a tool to diagnose complement activation. We discovered enhanced C3b and C4d deposition on erythrocytes in COVID-19 sepsis patients and non-COVID sepsis patients compared with healthy controls, supporting the role of complement in sepsis-associated organ injury. Our data suggest that erythrocytes may contribute to a precision medicine approach to sepsis and have diagnostic value in monitoring complement dysregulation in COVID-19-sepsis and non-COVID sepsis and identifying patients who may benefit from complement targeted therapies.

引用

页码：L485 / L489

页数：5

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