Application of a process friendly morpholine synthesis to (S,S)-Reboxetine

被引：19

作者：

Assaf, Georges ^{[1
]}

Cansell, Gemma ^{[1
]}

Critcher, Doug ^{[1
]}

Field, Stuart ^{[1
]}

Hayes, Stewart ^{[1
]}

Mathew, Suju ^{[1
]}

Pettman, Alan ^{[1
]}

机构：

[1] Pfizer Ltd, Dept Chem Res & Dev, Sandwich CT13 9NJ, Kent, England

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 38期

关键词：

REDUCTIVE CLEAVAGE; ACETALS; KETALS; ETHERS;

D O I：

10.1016/j.tetlet.2010.07.106

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report our results on the construction of a morpholine ring system from the corresponding epoxide and amino alcohol. From this study, we were able to convert a previous four-step synthesis into a more efficient two-step process. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5048 / 5051

页数：4

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