Coevolution and HBV drug resistance

被引：27

作者：

Khudyakov, Yury ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30333 USA

来源：

ANTIVIRAL THERAPY | 2010年 / 15卷 / 03期

关键词：

HEPATITIS-B-VIRUS; REGULATORY T-CELLS; CLONAL INTERFERENCE; RNA VIRUSES; NATURAL-HISTORY; C VIRUS; SUPERINFECTION EXCLUSION; HEPADNAVIRUS INFECTION; MUTATIONAL ROBUSTNESS; LAMIVUDINE TREATMENT;

D O I：

10.3851/IMP1515

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A high rate of mutation sets a strong foundation for the development of resistance to antiviral drugs. However, the ubiquitous presence of drug resistance mutations in the HBV population does not explain variations in the rate and specific types of drug resistance among patients. These variations can be explained by consideration of coevolution among individual sites in the HBV genome, viral variants and subpopulations, as well as coevolution between the entire intrahost HBV population and the host. The concept of coevolution offers a more complete framework for understanding drug resistance.

引用

页码：505 / 515

页数：11

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