Synergy Between Cannabidiol, Cannabidiolic Acid, and Δ9-Tetrahydrocannabinol in the Regulation of Emesis in the Suncus Murinus (House Musk Shrew)

被引：21

作者：

Rock, Erin M. ^{[1
,2
]}

Parker, Linda A. ^{[1
,2
]}

机构：

[1] Univ Guelph, Dept Psychol, Guelph, ON N1G 2W1, Canada

[2] Univ Guelph, Collaborat Neurosci Program, Guelph, ON N1G 2W1, Canada

来源：

BEHAVIORAL NEUROSCIENCE | 2015年 / 129卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

cannabidiolic acid; cannabidiol; Delta(9)-Tetrahydrocannabinol; Suncus murinus; shrew; vomiting; NAUSEA-INDUCED BEHAVIOR; CANNABINOIDS; ONDANSETRON; RATS;

D O I：

10.1037/bne0000057

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Smoked marijuana contains over 100 different cannabinoids, including the psychoactive compound Delta(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC, CBD, and its acidic precursor, cannabidiolic acid (CBDA), have all been shown to have antiemetic properties in the Suncus murinus (S. murinus; house musk shrew). Here we show that when subthreshold antiemetic doses of CBD (2.5 mg/kg ip) or CBDA (0.05 mg/kg ip) are combined with a subthreshold antiemetic dose of THC (1 mg/kg ip) in the S. murinus, both lithium-chloride-induced vomiting and abdominal retching are dramatically suppressed. These results suggest that combined effects of these compounds may lead to better control of vomiting with fewer side effects.

引用

页码：368 / 370

页数：3

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