Percutaneous Left Atrial Appendage Closure With the LAmbre Device for Stroke Prevention in Atrial Fibrillation A Prospective, Multicenter Clinical Study

被引：74

作者：

Huang, He ^{[1
,2
,3
]}

Liu, Yu ^{[1
,2
,3
]}

Xu, Yawei ^{[4
]}

Wang, Zulu ^{[5
]}

Li, Yigang ^{[6
]}

Cao, Kejiang ^{[7
]}

Zhang, Shu ^{[8
,9
]}

Yang, Yanzong ^{[10
]}

Yang, Xinchun ^{[11
]}

Huang, Dejia ^{[12
]}

Yu, Bo ^{[13
]}

Su, Xi ^{[14
]}

Wu, Liqun ^{[15
]}

Huang, Congxin ^{[1
,2
,3
]}

机构：

[1] Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan, Hubei, Peoples R China

[2] Wuhan Univ, Cardiovasc Res Inst, Wuhan, Hubei, Peoples R China

[3] Hubei Key Lab Cardiol, Wuhan, Hubei, Peoples R China

[4] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiol, Shanghai, Peoples R China

[5] Gen Hosp Shenyang Mil Reg, Dept Cardiol, Shenyang, Liaoning, Peoples R China

[6] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Cardiol, Shanghai, Peoples R China

[7] Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China

[8] Chinese Acad Med Sci, State Key Lab Cardiovasc Dis, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Beijing, Peoples R China

[9] Peking Union Med Coll, Beijing, Peoples R China

[10] Dalian Med Univ, Affiliated Hosp 1, Dept Cardiol, Dalian, Peoples R China

[11] Capital Med Univ, Chaoyang Hosp, Dept Cardiol, Beijing, Peoples R China

[12] Sichuan Univ, West China Hosp, Dept Cardiol, Chengdu, Sichuan, Peoples R China

[13] Harbin Med Univ, Affiliated Hosp 2, Dept Cardiol, Harbin, Heilongjiang, Peoples R China

[14] Wuhan Asian Heart Hosp, Dept Cardiol, Wuhan, Hubei, Peoples R China

[15] Shanghai Jiao Tong Univ, Sch Med, Dept Cardiol, Ruijin Hosp, Shanghai, Peoples R China

来源：

JACC-CARDIOVASCULAR INTERVENTIONS | 2017年 / 10卷 / 21期

基金：

中国国家自然科学基金;

关键词：

atrial fibrillation; LAmbre; left atrial appendage closure; stroke; AMPLATZER CARDIAC PLUG; WARFARIN THERAPY; ANTICOAGULATION THERAPY; RISK STRATIFICATION; PREDICTING STROKE; WATCHMAN DEVICE; TRIAL; THROMBUS; OCCLUSION; REGISTRY;

D O I：

10.1016/j.jcin.2017.06.072

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVES The authors sought to assess the clinical outcomes of left atrial appendage (LAA) closure with the LAmbre closure system in patients with nonvalvular atrial fibrillation (NVAF).& para;& para;BACKGROUND Over 90% of thrombi are located in the LAA in NVAF patients.& para;& para;METHODS A prospective, multicenter study was conducted in 153 NVAF patients with CHADS(2) score >= 1.& para;& para;RESULTS The LAA was successfully occluded in 152 patients. Serious complications occurred in 5 patients. During the 12-month follow-up, ischemic stroke occurred in 2 patients, 1 patient had incomplete LAA sealing, and there was no device embolization.& para;& para;CONCLUSIONS LAA closure with the LAmbre device shows encouraging results for stroke prevention. (C) 2017 Published by Elsevier on behalf of the American College of Cardiology Foundation.

引用

页码：2188 / 2194

页数：7

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