First and repeat liver resection for primary and recurrent intrahepatic cholangiocarcinoma

被引：39
作者：
Souche, Regis [1 ]
Addeo, Pietro [2 ]
Oussoultzoglou, Elie [2 ]
Herrero, Astrid [1 ]
Rosso, Edoardo [2 ]
Navarro, Francis [1 ]
Fabre, Jean Michel [1 ]
Bachellier, Philippe [2 ]
机构：
[1] Univ Montpellier I, Hop St Eloi, Hop Univ Montpellier, Dept Surg & Liver Transplantat, 80 Ave Augustin Fliche, F-34295 Montpellier 5, France
[2] Univ Strasbourg, Hepatopancreatobiliary Surg & Liver Transplantat, Hop Univ Strasbourg, Pole Pathol Digest Hepat & Transplantat,Hop Haute, Strasbourg, France
来源：
AMERICAN JOURNAL OF SURGERY | 2016年 / 212卷 / 02期
关键词：
Intrahepatic cholangiocarcinoma; Liver resection; Recurrent cholangiocarcinoma; Repeat hepatectomy; Survival; Risk factors for recurrence; SINGLE-CENTER EXPERIENCE; LONG-TERM SURVIVAL; PHASE-II TRIAL; RADIOFREQUENCY ABLATION; SURGICAL-MANAGEMENT; HEPATIC RESECTION; HEPATECTOMY; INSTITUTION; MORTALITY; CRITERIA;
D O I：
10.1016/j.amjsurg.2015.07.016
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
BACKGROUND: Recurrence after resection of intrahepatic cholangiocarcinoma (ICC) remains common. The present study sought to evaluate risk factors for recurrence and the results of repeat liver resection (RLR) for recurrent ICC. METHODS: Between 1997 and 2012, clinical data and outcomes of 125 consecutive patients undergoing liver resection for ICC were retrospectively analyzed. RESULTS: The rate of R0 resection was 89% (n = 110). Overall median survival was 35 months, and 1-, 3-, and 5-year actuarial survival rates were 80%, 48%, and 28%, respectively. Recurrence occurred in 76 patients (63.5%) and was intrahepatic only for 39 patients (51%). Tumor size greater than 5 cm was identified as an independent risk factor for recurrence (P <= .0001). RLR for recurrent ICC was feasible in 10 patients (25%) with a median survival after recurrence of 25 months (16 to 76). CONCLUSIONS: Tumor size more than 5 cm represents an independent risk factor for recurrence after resection of ICC. RLR in case of recurrent ICC, when feasible, is associated with longer overall survival. (C) 2015 Elsevier Inc. All rights reserved.
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收藏
页码：221 / 229
页数：9
相关论文
共 41 条
[1]   The "50-50 criteria" on postoperative day 5 - An accurate predictor of liver failure and death after hepatectomy [J].
Balzan, S ;
Belghiti, J ;
Farges, O ;
Ogata, S ;
Sauvanet, A ;
Delefosse, D ;
Durand, F .
ANNALS OF SURGERY, 2005, 242 (06) :824-829
[2]   Radiofrequency ablation of intrahepatic cholangiocarcinoma: feasability, local tumor control, and long-term outcome [J].
Butros, Selim R. ;
Shenoy-Bhangle, Anuradha ;
Mueller, Peter R. ;
Arellano, Ronald S. .
CLINICAL IMAGING, 2014, 38 (04) :490-494
[3]  
CHERQUI D, 1995, ARCH SURG-CHICAGO, V130, P1073
[4]   Survival Analysis of Intrahepatic Cholangiocarcinoma After Resection [J].
Cho, Seong Yeon ;
Park, Sang-Jae ;
Kim, Seong Hoon ;
Han, Sung-Sik ;
Kim, Young-Kyu ;
Lee, Kwang-Woong ;
Lee, Soon-Ae ;
Hong, Eun Kyung ;
Lee, Woo Jin ;
Woo, Sang Myung .
ANNALS OF SURGICAL ONCOLOGY, 2010, 17 (07) :1823-1830
[5]   Cholangiocarcinoma - Thirty-one-year experience with 564 patients at a single institution [J].
DeOliveira, Michelle L. ;
Cunningham, Steven C. ;
Cameron, John L. ;
Kamangar, Farin ;
Winter, Jordan M. ;
Lillemoe, Keith D. ;
Choti, Michael C. ;
Yeo, Charles J. ;
Schulick, Richard D. .
ANNALS OF SURGERY, 2007, 245 (05) :755-762
[6]   Classification of surgical complications - A new proposal with evaluation in a cohort of 6336 patients and results of a survey [J].
Dindo, D ;
Demartines, N ;
Clavien, PA .
ANNALS OF SURGERY, 2004, 240 (02) :205-213
[7]   New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1) [J].
Eisenhauer, E. A. ;
Therasse, P. ;
Bogaerts, J. ;
Schwartz, L. H. ;
Sargent, D. ;
Ford, R. ;
Dancey, J. ;
Arbuck, S. ;
Gwyther, S. ;
Mooney, M. ;
Rubinstein, L. ;
Shankar, L. ;
Dodd, L. ;
Kaplan, R. ;
Lacombe, D. ;
Verweij, J. .
EUROPEAN JOURNAL OF CANCER, 2009, 45 (02) :228-247
[8]   Intrahepatic Cholangiocarcinoma Primary Liver Resection and Aggressive Multimodal Treatment of Recurrence Significantly Prolong Survival [J].
Ercolani, Giorgio ;
Vetrone, Gaetano ;
Grazi, Gian Luca ;
Aramaki, Osamu ;
Cescon, Matteo ;
Ravaioli, Matteo ;
Serra, Carla ;
Brandi, Giovanni ;
Pinna, Antonio Daniele .
ANNALS OF SURGERY, 2010, 252 (01) :107-114
[9]   Irinotecan with 5-FU/FA in advanced biliary tract adenocarcinomas -: A multicenter phase II trial [J].
Feisthammel, Juergen ;
Schoppmeyer, Konrad ;
Moessner, Joachim ;
Schulze, Manfred ;
Caca, Karel ;
Wiedmann, Marcus .
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2007, 30 (03) :319-324
[10]   Preoperative contralateral portal vein embolization before major hepatic resection is a safe and efficient procedure: A large single institution experience [J].
Giraudo, Giorgio ;
Greget, Michel ;
Oussoultzoglou, Elie ;
Rosso, Edoardo ;
Bachellier, Philippe ;
Jaeck, Daniel .
SURGERY, 2008, 143 (04) :476-482
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