Peripheral blood stem cell mobilization with granulocyte colony-stimulating factor and a harvesting procedure in pediatric donors

被引：0

作者：

Kawano, Y

Takaue, Y

Watanabe, T

Watanabe, A

Iwai, A

Kuroda, Y

机构：

[1] Akita Univ, Dept Pediat, Akita 010, Japan

[2] Kagawa Childrens Hosp, Kagawa, Japan

[3] Univ Tokushima, Dept Pediat, Tokushima 770, Japan

来源：

BONE MARROW TRANSPLANTATION | 1998年 / 21卷

关键词：

peripheral blood stem cell; G-CSF; pediatric donor; apheresis;

D O I：

暂无

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The safety of injecting healthy donors with granulocyte colony-stimulating factor (G-CSF) has not been established, To evaluate PBSC mobilization and harvesting efficacy in the pediatric population, we compared it with those in adult donors. In this study, we conclude that PBSC mobilization and harvesting protocol in normal pediatric donors can be performed safely and effectively. Considering the lower frequency of side-effects and WBC counts, and G-CSF kinetics, higher dose of G-CSF would be recommended when small children become donors for adult patients.

引用

页码：S32 / S34

页数：3

共 7 条

[1]

Becker P S, 1997, Biol Blood Marrow Transplant, V3, P45

[2] Blood and marrow transplantation activity in Europe 1995 [J].

Gratwohl, A ;

Hermans, J ;

Baldomero, H .

BONE MARROW TRANSPLANTATION, 1997, 19 (05) :407-419

[3] New consecutive high-dose chemotherapy modality with fractionated blood stem cell support in the treatment of high-risk pediatric solid tumors: a feasibility study [J].

Kajiume, T ;

Kawano, Y ;

Takaue, Y ;

Abe, T ;

Watanabe, T ;

Okamoto, Y ;

Makimoto, A ;

Suenaga, K ;

Suzuya, H ;

Sato, J ;

Yokobayashi, A ;

Hashimoto, T ;

Yoshida, K ;

Ishibashi, H ;

Takehara, H ;

Tashiro, S ;

Kuroda, Y .

BONE MARROW TRANSPLANTATION, 1998, 21 (02) :147-151

[4] Treatment of normal individuals with granulocyte-colony-stimulating factor: Donor experiences and the effects on peripheral blood CD34+ cell counts and on the collection of peripheral blood stem cells [J].

Stroncek, DF ;

Clay, ME ;

Petzoldt, ML ;

Smith, J ;

Jaszcz, W ;

Oldham, FB ;

McCullough, J .

TRANSFUSION, 1996, 36 (07) :601-610

[5] COLLECTION AND TRANSPLANTATION OF PERIPHERAL-BLOOD STEM-CELLS IN VERY SMALL CHILDREN WEIGHING 20 KG OR LESS [J].

TAKAUE, Y ;

KAWANO, Y ;

ABE, T ;

OKAMOTO, Y ;

SUZUE, T ;

SHIMIZU, T ;

SAITO, S ;

SATO, J ;

MAKIMOTO, A ;

NAKAGAWA, R ;

WATANABE, T ;

ITO, M ;

KURODA, Y .

BLOOD, 1995, 86 (01) :372-380

[6]

TAKAUE Y, 1995, HEMATOPOIETIC STEM C, P611

[7] The biology and clinical uses of blood stem cells [J].

To, LB ;

Haylock, D ;

Simmons, PJ ;

Juttner, CA .

BLOOD, 1997, 89 (07) :2233-2258

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