Synthesis, Characterization and Biological Activity of Pr(III) Complex Constructed by Pyridine-2,6-dicarboxylate

被引：1

作者：

Zhang Li ^{[1
]}

Guo Lin-Feng ^{[1
]}

Huang Sheng ^{[1
]}

Kang Jie ^{[1
]}

Sun Wei-Ming ^{[1
]}

机构：

[1] Fujian Med Univ, Sch Pharm, Fujian Key Lab Drug Target Discovery & Struct & F, Fuzhou 350108, Peoples R China

来源：

CHINESE JOURNAL OF INORGANIC CHEMISTRY | 2021年 / 37卷 / 07期

关键词：

praseodymium(III) complex; crystal structure; antitumor activity; theoretical calculation; METAL-ORGANIC FRAMEWORKS; COORDINATION POLYMERS; CRYSTAL-STRUCTURES; MAGNETIC-PROPERTIES; CELLS;

D O I：

10.11862/CJIC.2021.139

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A novel Pr(III)-based co-crystal complex, (H(2)pipz)(1.5)[Pr(pdc)(3)]center dot 7H(2)O (1, pdc(2-)=pyridine-2,6-dicarboxylate and pipz=piperazine) has been synthesized under hydrothermal condition. Infrared (IR) spectroscopy, elemental analysis, and X-ray single. crystal diffraction were carried out to determine the composition and crystal structure of complex 1. To deeply reveal the electronic structure of complex 1, density functional theory (DFT) calculations were employed to investigate the electrostatic potential (ESP) and frontier molecular orbitals (FMO) of the structural unit [Pr(pdc)(3)](3-). More importantly, the antitumor test showed that complex 1 exhibited good cytotoxic activity against K562 (IC50=(61.3 +/- 10.2) mu g.mL(-1)) and OE-19 cells (IC50=(15.9 +/- 3.2) mu g.mL(-1)), especially more effective against OE. 19 cells.

引用

页码：1269 / 1276

页数：8

共 38 条

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