Neuroprotective Effects of Choline and Other Methyl Donors

被引：80

作者：

Bekdash, Rola A. ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Biol Sci, Newark, NJ 07102 USA

来源：

NUTRIENTS | 2019年 / 11卷 / 12期

关键词：

brain; choline; dementia; epigenetics; methyl-donors; nutrition; neuroprotection; PRENATAL ALCOHOL EXPOSURE; ONE-CARBON METABOLISM; TS65DN MOUSE MODEL; ALZHEIMERS-DISEASE; DNA-METHYLATION; GENE-EXPRESSION; BEHAVIORAL ALTERATIONS; NEURON MORPHOLOGY; MEMORY IMPAIRMENT; CHILD COGNITION;

D O I：

10.3390/nu11122995

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Recent evidence suggests that physical and mental health are influenced by an intricate interaction between genes and environment. Environmental factors have been shown to modulate neuronal gene expression and function by epigenetic mechanisms. Exposure to these factors including nutrients during sensitive periods of life could program brain development and have long-lasting effects on mental health. Studies have shown that early nutritional intervention that includes methyl-donors improves cognitive functions throughout life. Choline is a micronutrient and a methyl donor that is required for normal brain growth and development. It plays a pivotal role in maintaining structural and functional integrity of cellular membranes. It also regulates cholinergic signaling in the brain via the synthesis of acetylcholine. Via its metabolites, it participates in pathways that regulate methylation of genes related to memory and cognitive functions at different stages of development. Choline-related functions have been dysregulated in some neurodegenerative diseases suggesting choline role in influencing mental health across the lifespan.

引用

页数：16

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