Severe schistosomiasis in the absence of interleukin-4 (IL-4) is IL-12 independent

被引：21
作者：
Patton, EA
Brunet, LR
La Flamme, AC
Pedras-Vasconcelos, J
Kopf, M
Pearce, EJ
机构：
[1] Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USA
[2] Basel Inst Immunol, Basel, Switzerland
来源：
INFECTION AND IMMUNITY | 2001年 / 69卷 / 01期
关键词：
D O I：
10.1128/IAI.69.1.589-592.2001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
An interleukin-4 (IL-4)-dependent Th2 response allows wild-type mice to survive infection with the parasite Schistosoma mansoni. In the absence of IL-4, infected mice mount a Th1-like proinflammatory response, develop severe disease, and succumb. Neither the Th1 response nor morbidity is IL-12 dependent in this system.
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页码：589 / 592
页数：4
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