The incidence of esophagogastric junction adenocarcinoma (AEG) is increasing worldwide. Barrett's esophagus (BE) associated with dysplasia is the main risk factor for the development of cancer. Currently, screening programs to individuate and eradicate BE represent the best way to reduce AEG cancer. Several endoscopic approaches are here discussed. Surgical strategies for different types of AEG cancer are now fairly standardized, and multidisciplinary strategies using chemotherapy or chemoradiotherapy may improve the outcome of these patients. Here we briefly discuss the keypoints, main topics, and critical issues, according to accumulating evidence and taking into account our own experience.
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Division of Surgical, Department of Anesthesiological, Surgical and Emergency Sciences, School of Medicine, Second University of NaplesDivision of Medical Oncology, Department of Internal and Experimental Medicine “F. Magrassi”, School of Medicine, Second University of Naples
Gennaro Galizia
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Eva Lieto
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Ferdinando De Vita
Fortunato Ciardiello
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Division of Medical Oncology, Department of Internal and Experimental Medicine “F. Magrassi”, School of Medicine, Second University of NaplesDivision of Medical Oncology, Department of Internal and Experimental Medicine “F. Magrassi”, School of Medicine, Second University of Naples
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Pathology and Laboratory Medicine Service,VA CT Healthcare SystemDepartment of Pathology, Yale University School of Medicine
Antonio Galvao Neto
Xuchen Zhang
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Department of Pathology, Yale University School of Medicine
Department of Pathology, New York University School of MedicineDepartment of Pathology, Yale University School of Medicine