Towards understanding the molecular basis of bacterial DNA segregation

被引：61

作者：

Leonard, TA ^{[1
]}

Moller-Jensen, J ^{[1
]}

Löwe, J ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2005年 / 360卷 / 1455期

关键词：

Soj; Spo0J; ParAB; MinCDE; partitioning system; chromosome segregation;

D O I：

10.1098/rstb.2004.1608

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Bacteria ensure the fidelity of genetic inheritance by the coordinated control of chromosome segregation and cell division. Here, we review the molecules and mechanisms that govern the correct subcellular positioning and rapid separation of newly replicated chromosomes and plasmids towards the cell poles and, significantly, the emergence of mitotic-like machineries capable of segregating plasmid DNA. We further describe surprising similarities between proteins involved in DNA partitioning (ParA/ParB) and control of cell division (MinD/MinE), suggesting a mechanism for intracellular positioning common to the two processes. Finally, we discuss the role that the bacterial cytoskeleton plays in DNA partitioning and the missing link between prokaryotes and eukaryotes that is bacterial mechano-chemical motor proteins.

引用

页码：523 / 535

页数：13

共 132 条

[11] The divIVA minicell locus of Bacillus subtilis
Cha, JH
Stewart, GC
[J]. JOURNAL OF BACTERIOLOGY, 1997, 179 (05) : 1671 - 1683
[12] Crystal structure of the bacterial cell division regulator MinD
Cordell, SC
Löwe, J
[J]. FEBS LETTERS, 2001, 492 (1-2) : 160 - +
[13] DAVEY MJ, 1994, J BIOL CHEM, V269, P29908
[14] DAVIS GM, 1996, P ICIP, V1, P21
[15] BIOCHEMICAL ACTIVITIES OF THE PARA PARTITION PROTEIN OF THE P1 PLASMID
DAVIS, MA
MARTIN, KA
AUSTIN, SJ
[J]. MOLECULAR MICROBIOLOGY, 1992, 6 (09) : 1141 - 1147
[16] RECOGNITION OF THE P1 PLASMID CENTROMERE ANALOG INVOLVES BINDING OF THE PARB PROTEIN AND IS MODIFIED BY A SPECIFIC HOST FACTOR
DAVIS, MA
AUSTIN, SJ
[J]. EMBO JOURNAL, 1988, 7 (06) : 1881 - 1888
[17] An Src homology 3-like domain is responsible for dimerization of the repressor protein KorB encoded by the promiscuous IncP plasmid RP4
Delbrück, H
Ziegelin, G
Lanka, E
Heinemann, U
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (06) : 4191 - 4198
[18] Does RNA polymerase help drive chromosome segregation in bacteria?
Dworkin, J
Losick, R
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (22) : 14089 - 14094
[19] ParB-stimulated nucleotide exchange regulates a switch in functionally distinct ParA activities
Easter, J
Gober, JW
[J]. MOLECULAR CELL, 2002, 10 (02) : 427 - 434
[20] The double par locus of virulence factor pB171:: DNA segregation is correlated with oscillation of ParA
Ebersbach, G
Gerdes, K
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (26) : 15078 - 15083

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