Towards understanding the molecular basis of bacterial DNA segregation

被引：61
作者：
Leonard, TA [1 ]
Moller-Jensen, J [1 ]
Löwe, J [1 ]
机构：
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
来源：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2005年 / 360卷 / 1455期
关键词：
Soj; Spo0J; ParAB; MinCDE; partitioning system; chromosome segregation;
D O I：
10.1098/rstb.2004.1608
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Bacteria ensure the fidelity of genetic inheritance by the coordinated control of chromosome segregation and cell division. Here, we review the molecules and mechanisms that govern the correct subcellular positioning and rapid separation of newly replicated chromosomes and plasmids towards the cell poles and, significantly, the emergence of mitotic-like machineries capable of segregating plasmid DNA. We further describe surprising similarities between proteins involved in DNA partitioning (ParA/ParB) and control of cell division (MinD/MinE), suggesting a mechanism for intracellular positioning common to the two processes. Finally, we discuss the role that the bacterial cytoskeleton plays in DNA partitioning and the missing link between prokaryotes and eukaryotes that is bacterial mechano-chemical motor proteins.
引用
收藏
页码：523 / 535
页数：13
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