2-Hydroxyindoline-3-triethylammonium Bromide: A Reagent for Formal C3-Electrophilic Reactions of Indoles

被引：56

作者：

Abe, Takumi ^{[1
]}

Suzuki, Takuro ^{[2
]}

Anada, Masahiro ^{[2
]}

Matsunaga, Shigeki ^{[2
]}

Yamada, Koji ^{[1
]}

机构：

[1] Hlth Sci Univ Hokkaido, Fac Pharmaceut Sci, Ishikari, Hokkaido 0610293, Japan

[2] Hokkaido Univ, Fac Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 16期

关键词：

CONCISE TOTAL-SYNTHESIS; ONE-POT SYNTHESIS; N-ACETYL INDOLES; CASCADE; 2,3-DIALKYLINDOLES; HYDROARYLATION; CONSTRUCTION; CALOTHRIXINS; DIMERIZATION; DERIVATIVES;

D O I：

10.1021/acs.orglett.7b01940

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel indole-2,3-epoxide equivalent, 2-hydroxyindbline-3-triethylammonium bromide, was found, to be a convenient reagent for formal C3-electrophilic reactions of indoles with various nudeophiles. By taking advantage of the nudeophilie character of the oxygen of the 2-hydroxyindo-line the interrupted retro-Claisen interrupted Feist - Benary reactions, with 1,3-dicarbonyl compounds Were efficiently achieved.

引用

页码：4275 / 4278

页数：4

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