Synthesis of cyclohexanone-based cathepsin B inhibitors that interact with both the S and S′ binding sites

被引：14

作者：

Conroy, JL ^{[1
]}

Abato, P ^{[1
]}

Ghosh, M ^{[1
]}

Austermuhle, MI ^{[1
]}

Kiefer, MR ^{[1
]}

Seto, CT ^{[1
]}

机构：

[1] Brown Univ, Dept Chem, Providence, RI 02912 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 45期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(98)01783-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Solution and solid phase methods are described for the synthesis of inhibitors of the cysteine protease cathepsin B. These inhibitors are based on a cyclohexanone pharmacophore and are designed to interact with both the S and S' subsites of the enzyme active site. (C) 1998 Elsevier Science Ltd. All rights reserved.

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收藏

页码：8253 / 8256

页数：4

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