Monoolein: a magic lipid?

被引：344

作者：

Kulkarni, Chandrashekhar V. ^{[1
]}

Wachter, Wolfgang ^{[1
]}

Iglesias-Salto, Guillermo ^{[1
]}

Engelskirchen, Sandra ^{[2
]}

Ahualli, Silvia ^{[1
,3
]}

机构：

[1] Graz Univ, Dept Chem, A-8010 Graz, Austria

[2] Univ Stuttgart, Inst Phys Chem, D-70569 Stuttgart, Germany

[3] Univ Granada, Dept Appl Phys, Fac Sci, E-18071 Granada, Spain

来源：

PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2011年 / 13卷 / 08期

关键词：

MEMBRANE-PROTEIN CRYSTALLIZATION; BICONTINUOUS CUBIC PHASE; X-RAY-DIFFRACTION; TRANSFORM INFRARED-SPECTROSCOPY; TOPICAL DRUG-DELIVERY; SPONTANEOUS CURVATURE; EMULSIFIED MICROEMULSIONS; DIELECTRIC-SPECTROSCOPY; TRANSITION KINETICS; ELASTIC PROPERTIES;

D O I：

10.1039/c0cp01539c

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

During the last few years, there has been an extraordinary increase in publications describing the manifold applications of monoolein, one of the most important lipids in the fields of drug delivery, emulsion stabilization and protein crystallization. In this perspective we present a comprehensive review of the phase behavior of this 'magic lipid'. An account of various mesophases formed in the presence of water and a collection of formulae for the calculation of their nano-structural parameters are provided. Effects of chemical and biological molecules including lipids, detergents, salts, sugars, proteins and DNA on the classical behavior are also discussed. Physicochemical triggers such as, temperature, pressure and shearing modulate the phase behavior of monoolein self assemblies that are covered in subsequent sections. Finally the growing applications of monoolein in various fields are also reported.

引用

页码：3004 / 3021

页数：18

共 241 条

[1] Simultaneous small-angle/wide-angle X-ray scattering and differential scanning calorimetry study of the effects of glycerol on hydrated monoolein [J].