Facile synthesis of 2-bromoindoles by ligand-free CuI-catalyzed intramolecular cross-coupling of gem-dibromoolefins

被引：20
|
作者：
Jiang, Baishan [2 ]
Tao, Kemei [2 ]
Shen, Wang [1 ]
Zhang, Jiancun [2 ,3 ]
机构：
[1] Kanion USA Inc, Hayward, CA 94080 USA
[2] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China
[3] Guangzhou Med Univ, State Key Lab Resp Dis, Guangzhou 510120, Peoples R China
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 48期
关键词：
REGIOSPECIFIC BROMINATION; EFFICIENT SYNTHESIS; INDOLES; 1,1-DIBROMO-1-ALKENES; DERIVATIVES; INHIBITORS; 3-METHYLINDOLES; NITROGEN;
D O I：
10.1016/j.tetlet.2010.09.129
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mild and efficient synthesis of 2-bromoindoles by ligand-free CuI-catalyzed intramolecular cross-coupling of gem-dibromoolefins was developed. Reactions were carried out in toluene at room temperature and the corresponding 2-bromoindoles were obtained in excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6342 / 6344
页数：3
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