Synthesis of New Dihydropyrimido[4,5-b]quinolinetrione Derivatives Using a Four-Component Coupling Reaction

被引：37

作者：

Khalafi-Nezhad, A. ^{[1
]}

Panahi, F. ^{[1
]}

机构：

[1] Shiraz Univ, Coll Sci, Dept Chem, Shiraz 71454, Iran

来源：

SYNTHESIS-STUTTGART | 2011年 / 06期

关键词：

multicomponent reaction; pyrimidine; dihydropyridine; barbituric acid; dimedone; DIVERSITY-ORIENTED SYNTHESIS;

D O I：

10.1055/s-0030-1258446

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient and one-pot method for the efficient synthesis of the novel 8,9-dihydro-8,8-dimethyl-5,10-diphenylpyrimido[4,5-b]quinoline-2,4,6(1H,3H,5H,7H,10H)-trione derivatives via a four-component condensation reaction of aldehydes, amines, dimedone, and barbituric acid in the presence of tungestophosphoric acid (H3PW12O40) as catalyst is described. This new approach proceeded smoothly in good to excellent yields and the pure products are separated from the reaction mixture by simple filtration.

引用

收藏

页码：984 / 992

页数：9

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