Recent developments in neuronal nicotinic acetylcholine receptor modulators

被引：36

作者：

Lin, NH ^{[1
]}

Meyer, MD ^{[1
]}

机构：

[1] Abbott Labs, Neurol & Urol Dis Res, Abbott Pk, IL 60064 USA

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 1998年 / 8卷 / 08期

关键词：

ABT-089; ABT-418; ABT-594; Alzheimer's disease; cholinergic channel activator; epibatidine; GTS-21; nAChR; neuronal nicotinic acetylcholine receptor agonist; nicotine; neuronal nicotinic acetylcholine receptor; Parkinson's disease; RJR-2043; SIB-1765;

D O I：

10.1517/13543776.8.8.991

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The neuronal nicotinic acetylcholine receptor (nAChR), a member of the ligand-gated ion channel (LGIC) superfamily, is widely distributed throughout the central (CNS) and peripheral nervous systems. Recent advances in the understanding of the molecular diversity of this receptor family have created opportunities for the development of novel therapeutic agents for the treatment of a diverse set of disorders, including Alzheimer's dementia, Parkinson's disease (PD), addiction and pain. This article reviews the published patent literature, with particular emphasis on those developments that are likely to have the greatest impact on the development of novel therapeutics for CNS disorders.

引用

页码：991 / 1015

页数：25

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