Encapsulation of methotrexate loaded magnetic microcapsules for magnetic drug targeting and controlled drug release

被引：22

作者：

Chakkarapani, Prabu ^{[1
,2
]}

Subbiah, Latha ^{[1
,2
]}

Palanisamy, Selvamani ^{[1
,2
]}

Bibiana, Arputha ^{[1
,2
]}

Ahrentorp, Fredrik ^{[3
]}

Jonasson, Christian ^{[3
]}

Johansson, Christer ^{[3
]}

机构：

[1] Anna Univ, Dept Pharmaceut Technol, Tiruchirappalli 620024, Tamil Nadu, India

[2] Anna Univ, Ctr Excellence Nanobio Translational Res, Tiruchirappalli 620024, Tamil Nadu, India

[3] Acero Swedish ICT AB, SE-41133 Gothenburg, Sweden

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2015年 / 380卷

关键词：

MMC; Methotrexate; Polyelectrolyte; Layer-by-layer; Rheumatoid arthritis; POROUS CACO3 MICROPARTICLES; CALCIUM-CARBONATE; POLYELECTROLYTE MICROCAPSULES; BIODEGRADABLE MICROCAPSULES; DELIVERY; DNA; NANOPARTICLES; MICROSPHERES; DEGRADATION; PARTICLES;

D O I：

10.1016/j.jmmm.2014.11.006

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

We report on the development and evaluation of methotrexate magnetic microcapsules (MMC) for targeted rheumatoid arthritis therapy. Methotrexate was loaded into CaCO3-PSS (poly (sodium 4-styrenesullonate)) doped microparticles that were coated successively with poly (allylamine hydrochloride) and poly (sodium 4-styrenesulfonate) by layer-by-layer technique. Ferrofluid was incorporated between the polyelectrolyte layers. CaCO3-PSS core was etched by incubation with EDTA yielding spherical MMC. The MMC were evaluated for various physicochemical, pharmaceutical parameters and magnetic properties. Surface morphology, crystallinity, particle size, zeta potential, encapsulation efficiency, loading capacity, drug release pattern, release kinetics and AC susceptibility studies revealed spherical particles of 3 rim size were obtained with a net zeta potential of +24.5 mV, 56% encapsulation and 18.6% drug loading capacity, 96% of cumulative drug release obeyed Hixson-Crowell model release kinetics. Drug excipient interaction, surface area, thermal and storage stability studies for the prepared MMC was also evaluated. The developed MMC offer a promising mode of targeted and sustained release drug delivery for rheumatoid arthritis therapy. (C) 2014 Elsevier B.V. All rights reserved

引用

页码：285 / 294

页数：10

共 54 条

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