The utility and limitations of 18F-fluorodeoxyglucose positron emission tomography with computed tomography in patients with primary mediastinal B-cell lymphoma: single institution experience and literature review

被引：19

作者：

Cheah, Chan Y. ^{[1
,3
]}

Hofman, Michael S. ^{[2
,3
]}

Seymour, John F. ^{[1
,3
]}

Ritchie, David S. ^{[1
,3
]}

Dickinson, Michael ^{[1
,3
]}

Wirth, Andrew ^{[1
,3
]}

Prince, H. Miles ^{[1
,3
,4
,5
]}

Wolf, Max ^{[1
,3
]}

Januszcewicz, Elchanan H. ^{[1
]}

Carney, Dennis A. ^{[1
,3
]}

Herbert, Kirsten E. ^{[1
,3
,5
]}

Harrison, Simon J. ^{[1
,3
]}

Burbury, Kate L. ^{[1
,3
]}

Tam, Constantine S. ^{[1
,3
]}

机构：

[1] Peter MacCallum Canc Ctr, Dept Haematol, East Melbourne, Vic 8006, Australia

[2] Peter MacCallum Canc Ctr, Ctr Canc Imaging, East Melbourne, Vic 8006, Australia

[3] Univ Melbourne, Melbourne, Vic, Australia

[4] Monash Univ, Clayton, Vic, Australia

[5] Cabrini Hosp, Malvern, Vic, Australia

来源：

LEUKEMIA & LYMPHOMA | 2015年 / 56卷 / 01期

关键词：

Primary mediastinal B-cell lymphoma; PET-CT; interim PET-CT; prognostic factors; risk adapted therapy; non-Hodgkin lymphoma; SUV-BASED ASSESSMENT; F-18-FDG PET; FDG-PET; RITUXIMAB; CYCLOPHOSPHAMIDE; CHEMOTHERAPY; MULTICENTER; VINCRISTINE; DOXORUBICIN; PREDNISONE;

D O I：

10.3109/10428194.2014.910656

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There are limited data regarding the role of F-18-fluorodeoxyglucose positron emission tomography with computed tomography (FDG PET-CT) scanning in primary mediastinal B-cell lymphoma (PMBL). We analyzed 28 patients with PMBL treated with chemotherapy, of whom 25 (89%) also received rituximab and 17 (61%) radiotherapy. PET-CT scans were interpreted using visual analysis and a 5-point scale. After a median follow-up of 2.6 years, four patients relapsed and two died. The 2-year progression-free survival and overall survival were 86% and 94%. PET-CT has excellent negative predictive value (interim, 86-87%; end of treatment, 95%) but limited positive predictive value due to the high frequency of positive scans. Several patients with persistent metabolically active masses underwent biopsies, which showed necrosis but no lymphoma. Thus a negative PETCT is an excellent predictor of subsequent outcome. However, residual metabolically active masses after treatment should be biopsied to confi rm viable lymphoma prior to salvage therapy.

引用

页码：49 / 56

页数：8

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