Argatroban in thrombotic stroke

被引：5

作者：

LaMonte, MP ^{[1
]}

机构：

[1] Univ Maryland, Sch Med, Maryland Brain Attack Ctr, Div Emergency Med, Baltimore, MD 21201 USA

来源：

PATHOPHYSIOLOGY OF HAEMOSTASIS AND THROMBOSIS | 2002年 / 32卷

关键词：

stroke; cerebral blood flow; cerebral ischemia; thrombin; argatroban;

D O I：

10.1159/000069108

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Evidence for the potential use of direct thrombin inhibition in the treatment of acute stroke is reviewed. Reduction of secondary microthrombi and improved regional collateral cerebral blood flow is the proposed mechanism of action of thrombin inhibition for the treatment of cerebral ischemia. A clinical study in Japan found that argatroban administered within 48 h of stroke symptom onset is safe and effective in reducing neurological impairment due to ischemic stroke. The implications of further clinical studies are discussed. Copyright (C) 2002 S. Karger AG, Basel.

引用

页码：39 / 45

页数：7

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