Realistic Lenalidomide Dose Adjustment Strategy for Transplant-Ineligible Elderly Patients with Relapsed/Refractory Multiple Myeloma: Japanese Real-World Experience

被引：11

作者：

Nakaya, Aya ^{[1
]}

Fujita, Shinya ^{[1
]}

Satake, Atsushi ^{[1
]}

Nakanishi, Takahisa ^{[1
]}

Azuma, Yoshiko ^{[1
]}

Tsubokura, Yukie ^{[1
]}

Hotta, Masaaki ^{[1
]}

Yoshimura, Hideaki ^{[1
]}

Ishii, Kazuyoshi ^{[1
]}

Ito, Tomoki ^{[1
]}

Nomura, Shosaku ^{[1
]}

机构：

[1] Kansai Med Univ, Dept Internal Med 1, 2-5-1 Shin Machi, Hirakata, Osaka 5731010, Japan

来源：

ACTA HAEMATOLOGICA | 2017年 / 138卷 / 01期

关键词：

Elderly; Lenalidomide; Reduced dose; Relapsed/refractory multiple myeloma; Transplant ineligibility; DEXAMETHASONE; SURVIVAL;

D O I：

10.1159/000477792

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lenalidomide is an immunomodulatory drug administered orally in the treatment of multiple myeloma. Some elderly patients require a reduced lenalidomide dose because of comorbidities and/or adverse events. This study investigated the actual dose of lenalidomide in elderly patients, finding that most received reduced (5-10 mg) doses. The most common reasons for dose reduction were renal dysfunction (54% of patients), fatigue (grade >= 3; 20%), hematologic disorder (grade >= 3; 14%), and rash (grade >= 3; 9%). Their median time to progression was 11.8 months and their median overall survival was 39.2 months. The overall response rate was 73%, including 17% with a complete response, 19% with a very good partial response, and 37% with a partial response. These results showed that, contrary to western countries, most patients were treated with a reduced dose of lenalidomide in Japan. However, it is suggested that continued treatment with a tolerable dose may yield favorable outcomes. (C) 2017 The Author(s) Published by S. Karger AG, Basel

引用

页码：55 / 60

页数：6

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