The multifaceted roles of the invariant chain CD74-More than just a chaperone

被引：166

作者：

Schroeder, Bernd ^{[1
]}

机构：

[1] Univ Kiel, Inst Biochem, Otto Hahn Pl 9, D-24118 Kiel, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2016年 / 1863卷 / 06期

关键词：

Invariant chain; Antigen presentation; Intramembrane proteolysis; Endosomal trafficking; Macrophage migration inhibitory factor; Cell migration; MIGRATION-INHIBITORY FACTOR; CLASS-II MOLECULES; SIGNAL-PEPTIDE-PEPTIDASE; B-CELL MATURATION; INTRAMEMBRANE PROTEASE SPPL2A; ANTIGEN-PROCESSING COMPARTMENTS; CATHEPSIN-S CONTROLS; HLA-DR ANTIGENS; DENDRITIC CELLS; CYTOPLASMIC TAIL;

D O I：

10.1016/j.bbamcr.2016.03.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The invariant chain (CD74) is well known for its essential role in antigen presentation by mediating assembly and subcellular trafficking of the MHCII complex. Beyond this, CD74 has also been implicated in a number of processes independent of MHCII. These include the regulation of endosomal trafficking, cell migration and cellular signalling as surface receptor of the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF). In several forms of cancer, CD74 is up-regulated and associated with enhanced proliferation and metastatic potential. In this review, an overview of the diverse biological functions of the CD74 protein is provided with a particular focus on how these may be regulated. In particular, proteolysis of CD74 will be discussed as a central mechanism to control the actions of this important protein at different levels. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：1269 / 1281

页数：13

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