Salicylic acid and PEG-contained polyanhydrides: Synthesis, characterization, and in vitro salicylic acid release

被引：10
作者：
Cai, QX [1 ]
Zhu, KJ [1 ]
Zhang, JX [1 ]
机构：
[1] Zhejiang Univ, Inst Polymer Sci, Hangzhou 310027, Peoples R China
来源：
DRUG DELIVERY | 2005年 / 12卷 / 02期
基金：
中国国家自然科学基金;
关键词：
colon-specific drug delivery; polyanhydride; polyethylene glycol; salicylic acid;
D O I：
10.1080/10717540490446107
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Poly [bi(o-carboxyphenyl)adipate-polyethylene glycol] anhydrides-P(BOCA-PEG)-polymeric drugs were synthesized and characterized by Fourier transformed infrared spectroscopy, NNIR, DSC, gel permeation chromatography etc. Salicylic acid loading efficiency of these polymers ranged from 43.5 % to 71.3 %, which was much higher than that of other polymeric drugs with salicylic acid. The in vitro release of salicylic acid from the polymers was carried out in buffer solutions with different pH values and rat gastrointestinal contents. The results showed the release rate of salicylic acid increased with the increase of PEG content in the polymers and the increase of pH value of degradation buffer solution. The rat cecal contents also greatly promoted the release of salicylic acid. In 0.1M phosphate buffer solution at pH8.0, 37degreesC containing 5% rat cecal contents, P(BOCA-PEG200)(80:20) had 15 % salicylic acid released in 21 hr, indicating its potential use in colon-specific salicylic acid delivery.
引用
收藏
页码：97 / 102
页数：6
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