Investigation of serum high-sensitive C-reactive protein levels across all mood states in bipolar disorder

被引：101
作者：
Cunha, Angelo B. [2 ]
Andreazza, Ana C. [1 ,3 ]
Gomes, Fabiano A. [1 ]
Frey, Benicio N. [4 ]
da Silveira, Leonardo E. [1 ]
Goncalves, Carlos A. [3 ]
Kapczinski, Flavio [1 ]
机构：
[1] Hosp Clin Porto Alegre, Ctr Pesquisas, Bipolar Disorders Program, BR-90035003 Porto Alegre, RS, Brazil
[2] Univ Fed Santa Maria, Ctr Ciencias Saude, Dept Neuropsychiat, BR-97105900 Santa Maria, RS, Brazil
[3] Univ Fed Rio Grande do Sul, Inst Ciencias Besicas Saude, Dept Biochem, BR-90035003 Porto Alegre, RS, Brazil
[4] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ H2A 2B4, Canada
来源：
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 2008年 / 258卷 / 05期
关键词：
bipolar disorder; high-sensitivity C-reactive protein; inflammation; mania; pathophysiology;
D O I：
10.1007/s00406-007-0797-0
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
There has been an increasing interest in the role of the immune and inflammatory systems in mood disorders. Mood episodes are associated with changes in acute phase proteins such as high-sensitivity C-reactive protein (hsCRP). The present study investigated serum hsCRP in manic, depressed, and euthymic BD patients as compared to matched healthy controls. Serum hsCRP was assessed using an ultrasensitive assay of particle-enhanced immunoturbidimetric latex agglutination. Serum hsCRP levels were increased in manic BD patients, as compared to euthymic, depressed patients and healthy controls (P < 0.001). These findings add to the notion that changes in the inflammatory system take place during acute episodes of mania.
引用
收藏
页码：300 / 304
页数：5
相关论文
共 46 条
[1]   Serum S100B and antioxidant enzymes in bipolar patients [J].
Andreazza, Ana Cristina ;
Cassini, Carina ;
Rosa, Adriane Ribeiro ;
Leite, Marina Conch ;
de Almeida, Lucia M. V. ;
Nardin, Patricia ;
Cunha, Angelo B. N. ;
Cereser, Keila Maria ;
Santin, Aida ;
Gottfried, Carmem ;
Salvador, Mirian ;
Kapczinski, Flavio ;
Goncalves, Carlos Alberto .
JOURNAL OF PSYCHIATRIC RESEARCH, 2007, 41 (06) :523-529
[2]   Effect of partially modified retro-inverso analogues derived from C-reactive protein on the induction of nitric oxide synthesis in peritoneal macrophages [J].
Arcoleo, F ;
Milano, S ;
DAgostino, P ;
Misiano, G ;
Cappelletti, S ;
Gromo, G ;
Marcucci, F ;
Leoni, F ;
Cillari, E .
BRITISH JOURNAL OF PHARMACOLOGY, 1997, 120 (07) :1383-1389
[3]   Similar frequency of abnormal correlation between serum leptin levels and BMI before and after olanzapine treatment in schizophrenia [J].
Baptista, Trino ;
Davila, Adriana ;
El Fakih, Yamily ;
Uzcategui, Euderruh ;
Rangel, Nairy N. ;
Olivares, Yamile ;
Galeazzi, Tatiana ;
Vargas, Doritza ;
Pena, Rocio ;
Marquina, David ;
Villarroel, Vanesa ;
Teneud, Luis ;
Beaulieu, Serge .
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 2007, 22 (04) :205-211
[4]   Medical progress: Bipolar disorder [J].
Belmaker, RH .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (05) :476-486
[5]  
Carlson NG, 1999, J IMMUNOL, V163, P3963
[6]   A Journal of Biological Invasions [J].
James T. Carlton .
Biological Invasions, 1999, 1 (1) :1-1
[7]   Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes [J].
Cunha, Angelo B. M. ;
Frey, Benicio N. ;
Andreazza, Ana C. ;
Goi, Julia D. ;
Rosa, Adriane R. ;
Goncalves, Carlos A. ;
Santin, Aida ;
Kapczinski, Flavio .
NEUROSCIENCE LETTERS, 2006, 398 (03) :215-219
[8]   C-reactive protein: a nontraditional serum marker of cardiovascular risk [J].
de Ferranti, Sarah D. ;
Rifai, Nader .
CARDIOVASCULAR PATHOLOGY, 2007, 16 (01) :14-21
[9]   Elevated serum levels of C-reactive protein are associated with mania symptoms in outpatients with bipolar disorder [J].
Dickerson, Faith ;
Stallings, Cassie ;
Origoni, Andrea ;
Boronow, John ;
Yolken, Robert .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2007, 31 (04) :952-955
[10]   Association among C-reactive protein, oxidative stress, and traditional risk factors in healthy Japanese subjects [J].
Dohi, Yasuaki ;
Takase, Hiroyuki ;
Sato, Koichi ;
Ueda, Ryuzo .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2007, 115 (01) :63-66
12345