Recent advances in N-heterocyclic carbene-based radical catalysis

被引：298

作者：

Ishii, Takuya ^{[1
]}

Nagao, Kazunori ^{[1
]}

Ohmiya, Hirohisa ^{[1
,2
]}

机构：

[1] Kanazawa Univ, Grad Sch Med Sci, Div Pharmaceut Sci, Kakuma Machi, Kanazawa, Ishikawa 9201192, Japan

[2] JST, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan

来源：

CHEMICAL SCIENCE | 2020年 / 11卷 / 22期

关键词：

ELECTRON-TRANSFER PROPERTIES; BETA-HYDROXYLATION; ACTIVE ALDEHYDES; INTERMEDIATE; MECHANISM; KETONES; ENALS;

D O I：

10.1039/d0sc01538e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In nature, a number of enzymes use thiamine diphosphate as a coenzyme to catalyze the pyruvate decarboxylation. The resultant enamine, a so-called "Breslow intermediate," is known to perform single electron transfer to various electron acceptors. Inspired by this enzymatic catalysis, N-heterocyclic carbene (NHC)-catalyzed radical reactions have been developed. This minireview highlights the recent progress and developments in NHC-based radical catalysis. This minireview is categorized according to the reaction types; oxidation type reaction and carbon-carbon bond formation through single electron transfer/radical-radical coupling.

引用

页码：5630 / 5636

页数：7

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