Decontamination with vaporized hydrogen peroxide is effective against Mycobacterium tuberculosis

被引：51

作者：

Kahnert, A. ^{[1
]}

Seiler, P. ^{[1
]}

Stein, M. ^{[1
]}

Aze, B. ^{[1
]}

McDonnell, G. ^{[1
]}

Kaufmann, S. H. E. ^{[1
]}

机构：

[1] Max Planck Inst Infect Biol, D-10117 Berlin, Germany

来源：

LETTERS IN APPLIED MICROBIOLOGY | 2005年 / 40卷 / 06期

关键词：

vaporized hydrogen peroxide; disinfection; animal room; room decontamination; inactivation;

D O I：

10.1111/j.1472-765X.2005.01683.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aims: To determine the efficacy of room fumigation with vaporized hydrogen peroxide (VHP) in decontamination of viable Mycobacterium tuberculosis. Methods and Results: About 8 x 10(4)-2.3 x 10(6) CFU of M. tuberculosis H37Rv and M. tuberculosis Beijing were dried in 10-mu l drops in tissue culture plates, placed in steam-permeable Tyvek pouches and distributed on laboratory surfaces. The room was exposed to VHP delivered by air conditioning. Different exposure conditions were tested. Exposure to VHP resulted in sterilization of the bacterial samples in three different test runs. Conclusions: VHP treatment is an effective means of reducing and eliminating room contaminations of M. tuberculosis. Significance and Impact of the Study: Fumigation with VHP represents an alternative to formaldehyde fumigation, particularly for decontamination of animal rooms in tuberculosis research laboratories.

引用

页码：448 / 452

页数：5

共 12 条

[1]

[Anonymous], 1991, DISINFECTION STERILI

[2]

Besra Gurdyal S., 1994, P285

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