The TRPC6 intronic polymorphism, associated with the risk of neurological disorders in systemic lupus erythematous, influences immune cell function

被引：11

作者：

Ramirez, Giuseppe A. ^{[1
,3
]}

Coletto, Lavinia A. ^{[3
]}

Bozzolo, Enrica P. ^{[1
]}

Citterio, Lorena ^{[4
]}

Carpini, Simona Delli ^{[4
]}

Zagato, Laura ^{[4
]}

Rovere-Querini, Patrizia ^{[1
,2
,3
]}

Lanzani, Chiara ^{[4
]}

Manunta, Paolo ^{[4
]}

Manfredi, Angelo A. ^{[1
,2
,3
]}

Sciorati, Clara ^{[2
]}

机构：

[1] IRCCS San Raffaele Hosp & Sci Inst, Unit Immunol Rheumatol Allergy & Rare Dis, Milan, Italy

[2] San Raffaele Hosp & Sci Inst, Div Immunol Transplantat & Infect Dis, Milan, Italy

[3] Univ Vita Salute San Raffaele, Milan, Italy

[4] IRCCS San Raffaele Hosp & Sci Inst, Unit Nephrol, Milan, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2018年 / 325卷

关键词：

TRPC6; Systemic lupus erythematous; Neuropsychiatric; Calcium; Apoptosis; Cytokines; Genetics; DISEASE-ACTIVITY INDEX; T-CELLS; TRANSCRIPTION FACTORS; GENETIC-VARIANTS; B-CELLS; CALCIUM; APOPTOSIS; COLLEGE; PATHWAY; CHANNEL;

D O I：

10.1016/j.jneuroim.2018.10.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Patients with systemic lupus erythematosus (SLE) carrying a TT genotype for the rs7925662 single nucleotide polymorphism (SNP) in the transient receptor potential canonical channel 6 (TRPC6) gene are more likely to develop neuropsychiatric manifestations (NPSLE). We functionally characterised the effects of TRPC6 on peripheral blood mononuclear cells from 18 patients with SLE and 8 healthy controls with a known genotype. TRPC6 influenced calcium currents, apoptosis rates and cytokine secretion in a disease- and genotype-dependent manner. Cells from TT patients with NPSLE were more dependent on TRPC6 for the generation of calcium currents.

引用

页码：43 / 53

页数：11

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