HBP2:: a new mammalian protein that complements the fission yeast MBF transcription complex

被引：14
作者：
Sánchez-Díaz, A
Blanco, MA
Jones, N
Moreno, S
机构：
[1] Univ Salamanca, Inst Microbiol Bioquim, Dept Genet & Microbiol, CSIC,Edificio Departamental, Salamanca 37007, Spain
[2] Christie Hosp NHS Trust, Paterson Inst Canc Res, Manchester M20 4BX, Lancs, England
来源：
CURRENT GENETICS | 2001年 / 40卷 / 02期
关键词：
cell cycle; G1; transcription; cdc10; MBF; HMG box;
D O I：
10.1007/s002940100241
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The mammalian HBP2 gene has been isolated by functional complementation of cells unable to undergo DNA replication in fission yeast. HBP2 is a protein with a high mobility group (HMG) domain that belongs to the Sox (Sry-related HMG box) family of transcription factors. As in other members of the family, the HMG box in HBP2 is a DNA-binding domain that is essential for its function in Schizosaccharomyces pombe. Expression of HBP2 in fission yeast activates Cdc10-dependent transcription at G1/S and allows growth of cdc10-129, res1 Delta and rep2 Delta mutant cells at the restrictive temperature. The mammalian HBP2 activates transcription at G1/S in the fission yeast Sch. pombe.
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收藏
页码：110 / 118
页数：9
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