The epidemiology, diagnosis and treatment of COVID-19

被引：528

作者：

Zhai, Pan ^{[1
]}

Ding, Yanbing ^{[1
]}

Wu, Xia ^{[2
]}

Long, Junke ^{[3
]}

Zhong, Yanjun ^{[4
]}

Li, Yiming ^{[5
]}

机构：

[1] Hubei Prov Hosp Tradit Chinese Med, Dept Neurol, Wuhan 430073, Hubei, Peoples R China

[2] Hubei Prov Hosp Tradit Chinese Med, Dept Resp Med, Wuhan 430073, Hubei, Peoples R China

[3] Cent South Univ, Xiangya Hosp 2, Dept Cardiovasc Med, Changsha 410011, Hunan, Peoples R China

[4] Cent South Univ, Xiangya Hosp 2, ICU Ctr, Changsha 41001, Hunan, Peoples R China

[5] Wuhan Univ, Dept Crit Care Med, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2020年 / 55卷 / 05期

基金：

中国国家自然科学基金;

关键词：

COVID-19; Pandemic; Diagnosis; Isolation; Remdesivir; Clinical trials; CORTICOSTEROID TREATMENT; VIRAL-INFECTIONS; SPIKE PROTEIN; CHLOROQUINE; PNEUMONIA; CHINA; WUHAN; COV; AUTOMATION; REMDESIVIR;

D O I：

10.1016/j.ijantimicag.2020.105955

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In December 2019, the outbreak of the novel coronavirus disease (COVID-19) in China spread worldwide, becoming an emergency of major international concern. SARS-CoV-2 infection causes clusters of severe respiratory illness similar to severe acute respiratory syndrome coronavirus. Human-to-human transmission via droplets, contaminated hands or surfaces has been described, with incubation times of 2-14 days. Early diagnosis, quarantine, and supportive treatments are essential to cure patients. This paper reviews the literature on all available information about the epidemiology, diagnosis, isolation and treatments of COVID-19. Treatments, including antiviral agents, chloroquine and hydroxychloroquine, corticosteroids, antibodies, convalescent plasma transfusion and vaccines, are discussed in this article. In addition, registered trials investigating treatment options for COVID-19 infection are listed. (C) 2020 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

引用

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