The epidemiology, diagnosis and treatment of COVID-19

被引：528

作者：

Zhai, Pan ^{[1
]}

Ding, Yanbing ^{[1
]}

Wu, Xia ^{[2
]}

Long, Junke ^{[3
]}

Zhong, Yanjun ^{[4
]}

Li, Yiming ^{[5
]}

机构：

[1] Hubei Prov Hosp Tradit Chinese Med, Dept Neurol, Wuhan 430073, Hubei, Peoples R China

[2] Hubei Prov Hosp Tradit Chinese Med, Dept Resp Med, Wuhan 430073, Hubei, Peoples R China

[3] Cent South Univ, Xiangya Hosp 2, Dept Cardiovasc Med, Changsha 410011, Hunan, Peoples R China

[4] Cent South Univ, Xiangya Hosp 2, ICU Ctr, Changsha 41001, Hunan, Peoples R China

[5] Wuhan Univ, Dept Crit Care Med, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2020年 / 55卷 / 05期

基金：

中国国家自然科学基金;

关键词：

COVID-19; Pandemic; Diagnosis; Isolation; Remdesivir; Clinical trials; CORTICOSTEROID TREATMENT; VIRAL-INFECTIONS; SPIKE PROTEIN; CHLOROQUINE; PNEUMONIA; CHINA; WUHAN; COV; AUTOMATION; REMDESIVIR;

D O I：

10.1016/j.ijantimicag.2020.105955

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In December 2019, the outbreak of the novel coronavirus disease (COVID-19) in China spread worldwide, becoming an emergency of major international concern. SARS-CoV-2 infection causes clusters of severe respiratory illness similar to severe acute respiratory syndrome coronavirus. Human-to-human transmission via droplets, contaminated hands or surfaces has been described, with incubation times of 2-14 days. Early diagnosis, quarantine, and supportive treatments are essential to cure patients. This paper reviews the literature on all available information about the epidemiology, diagnosis, isolation and treatments of COVID-19. Treatments, including antiviral agents, chloroquine and hydroxychloroquine, corticosteroids, antibodies, convalescent plasma transfusion and vaccines, are discussed in this article. In addition, registered trials investigating treatment options for COVID-19 infection are listed. (C) 2020 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

引用

页数：13

共 90 条

[1] Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe [J].

Agnandji, S. T. ;

Huttner, A. ;

Zinser, M. E. ;

Njuguna, P. ;

Dahlke, C. ;

Fernandes, J. F. ;

Yerly, S. ;

Dayer, J. -A. ;

Kraehling, V. ;

Kasonta, R. ;

Adegnika, A. A. ;

Altfeld, M. ;

Auderset, F. ;

Bache, E. B. ;

Biedenkopf, N. ;

Borregaard, S. ;

Brosnahan, J. S. ;

Burrow, R. ;

Combescure, C. ;

Desmeules, J. ;

Eickmann, M. ;

Fehling, S. K. ;

Finckh, A. ;

Goncalves, A. R. ;

Grobusch, M. P. ;

Hooper, J. ;

Jambrecina, A. ;

Kabwende, A. L. ;

Kaya, G. ;

Kimani, D. ;

Lell, B. ;

Lemaitre, B. ;

Lohse, A. W. ;

Massinga-Loembe, M. ;

Matthey, A. ;

Mordmueller, B. ;

Nolting, A. ;

Ogwang, C. ;

Ramharter, M. ;

Schmidt-Chanasit, J. ;

Schmiedel, S. ;

Silvera, P. ;

Stahl, F. R. ;

Staines, H. M. ;

Strecker, T. ;

Stubbe, H. C. ;

Tsofa, B. ;

Zaki, S. ;

Fast, P. ;

Moorthy, V. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (17) :1647-1660

[2] Compounds with Therapeutic Potential against Novel Respiratory 2019 Coronavirus [J].

Angel Martinez, Miguel .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2020, 64 (05)

[3]

[Anonymous], 2020, Radiology, DOI DOI 10.1148/RADIOL.2020200642

[4]

[Anonymous], EMERGING INFECT DIS

[5] Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome [J].

Arabi, Yaseen M. ;

Mandourah, Yasser ;

Al-Hameed, Fahad ;

Sindi, Anees A. ;

Almekhlafi, Ghaleb A. ;

Hussein, Mohamed A. ;

Jose, Jesna ;

Pinto, Ruxandra ;

Al-Omari, Awad ;

Kharaba, Ayman ;

Almotairi, Abdullah ;

Al Khatib, Kasim ;

Alraddadi, Basem ;

Shalhoub, Sarah ;

Abdulmomen, Ahmed ;

Qushmaq, Ismael ;

Mady, Ahmed ;

Solaiman, Othman ;

Al-Aithan, Abdulsalam M. ;

Al-Raddadi, Rajaa ;

Ragab, Ahmed ;

Balkhy, Hanan H. ;

Al Harthy, Abdulrahman ;

Deeb, Ahmad M. ;

Al Mutairi, Hanan ;

Al-Dawood, Abdulaziz ;

Merson, Laura ;

Hayden, Frederick G. ;

Fowler, Robert A. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197 (06) :757-767

[6] Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20-28 January 2020 [J].

Backer, Jantien A. ;

Klinkenberg, Don ;

Wallinga, Jacco .

EUROSURVEILLANCE, 2020, 25 (05) :10-15

[7] Presumed Asymptomatic Carrier Transmission of COVID-19 [J].

Bai, Yan ;

Yao, Lingsheng ;

Wei, Tao ;

Tian, Fei ;

Jin, Dong-Yan ;

Chen, Lijuan ;

Wang, Meiyun .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (14) :1406-1407

[8] Real-Time Sequence-Validated Loop-Mediated Isothermal Amplification Assays for Detection of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) [J].

Bhadra, Sanchita ;

Jiang, Yu Sherry ;

Kumar, Mia R. ;

Johnson, Reed F. ;

Hensley, Lisa E. ;

Ellington, Andrew D. .

PLOS ONE, 2015, 10 (04)

[9] Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities [J].

Biot, C ;

Daher, W ;

Chavain, N ;

Fandeur, T ;

Khalife, J ;

Dive, D ;

De Clercq, E .

JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (09) :2845-2849

[10] Improved Molecular Diagnosis of COVID-19 by the Novel, Highly Sensitive and Specific COVID-19-RdRp/Hel Real-Time Reverse Transcription-PCR Assay Validated In Vitro and with Clinical Specimens [J].

Chan, Jasper Fuk-Woo ;

Yip, Cyril Chik-Yan ;

To, Kelvin Kai-Wang ;

Tang, Tommy Hing-Cheung ;

Wong, Sally Cheuk-Ying ;

Leung, Kit-Hang ;

Fung, Agnes Yim-Fong ;

Ng, Anthony Chin-Ki ;

Zou, Zijiao ;

Tsoi, Hoi-Wah ;

Choi, Garnet Kwan-Yue ;

Tam, Anthony Raymond ;

Cheng, Vincent Chi-Chung ;

Chan, Kwok-Hung ;

Tsang, Owen Tak-Yin ;

Yuen, Kwok-Yung .

JOURNAL OF CLINICAL MICROBIOLOGY, 2020, 58 (05)

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