Asymmetric synthesis of 2-substituted 4-chromanones using enzyme-catalyzed reactions

被引：11

作者：

Kawasaki, Masashi ^{[1
]}

Asano, Yuka ^{[2
]}

Katayama, Kanako ^{[2
]}

Inoue, Akihisa ^{[2
]}

Hiraoka, Chiho ^{[2
]}

Kakuda, Hiroko ^{[3
]}

Tanaka, Akira ^{[2
]}

Goto, Michimasa ^{[4
]}

Toyooka, Naoki ^{[5
]}

Kometani, Tadashi ^{[4
]}

机构：

[1] Toyama Prefectural Univ, Fac Engn, Dept Liberal Arts & Sci, Imizu, Toyama 9390398, Japan

[2] Toyama Prefectural Univ, Coll Technol, Dept Bioresources Sci, Imizu, Toyama 9390398, Japan

[3] Toyama Univ, Chem Lab, Toyama 9300194, Japan

[4] Toyama Natl Coll Technol, Dept Chem & Biochem Engn, Toyama 9398630, Japan

[5] Toyama Univ, Grad Sch Med & Pharmaceut Sci, Toyama 9300194, Japan

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2008年 / 54卷 / 3-4期

关键词：

asymmetric synthesis; chromanones; enzyme; hydrolysis; resolution;

D O I：

10.1016/j.molcatb.2007.12.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2-Substituted 4-chromanones were synthesized in their Optically active forms. The chiral intermediates were obtained via lipase-catalyzed enantioselective reactions. Lipase and esterase were also used for the hydrolysis of ester moieties of the precursors of the target compounds under mild conditions. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：93 / 102

页数：10

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