Synthesis of Highly Fused Pyrano[2,3-b]pyridines via Rh(III)- Catalyzed C-H Activation and Intramolecular Cascade Annulation under Room Temperature

被引：23

作者：

Han, Xu ^{[1
,2
,3
]}

Gao, Feng ^{[1
,2
]}

Li, Chunpu ^{[1
,2
,3
]}

Fang, Daqing ^{[1
,2
,4
]}

Xie, Xiong ^{[1
,2
,3
]}

Zhou, Yu ^{[1
,2
,3
]}

Liu, Hong ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China

[2] Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[4] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 10期

基金：

中国国家自然科学基金;

关键词：

BOND ACTIVATION; FUNCTIONALIZATION; 1,2,4-TRIAZINES; CONSTRUCTION; HETEROCYCLES; NITROGEN; ACCESS;

D O I：

10.1021/acs.joc.9b03102

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile access to the polycyclic-fused pyrano[2,3-b]pyridines has been established under room temperature via Rh(III)-catalyzed C-H bond activation and intramolecular cascade annulation. This strategy features high efficiency, unique versatility, and generality and it can occur under mild conditions in good to excellent yields. More importantly, this strategy can be extended to the late-stage functionalization of drugs possessing the CN group.

引用

页码：6281 / 6294

页数：14

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