The Pd-catalyzed synthesis of difluoroethyl and difluorovinyl compounds with a chlorodifluoroethyl iodonium salt (CDFI)

被引：9

作者：

Niu, Yaru ^{[1
,2
]}

Cao, Chengyao Kimmy ^{[2
]}

Ge, Chenxin ^{[2
]}

Qu, Hongmei ^{[1
]}

Chen, Chao ^{[2
,3
]}

机构：

[1] Tianjin Univ, Sch Chem Engn & Technol, Dept Pharmaceut Engn, Key Lab Syst Bioengn,Minist Educ, Tianjin 300350, Peoples R China

[2] Tsinghua Univ, Dept Chem, MOE, Key Lab Bioorgan Phosphorus Chem & Chem Biol,Mini, Beijing 100084, Peoples R China

[3] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2022年 / 33卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Iodonium salts; C-H activation; Pd-catalyzed; Difluoroethylation; Difluorovinylation; C-H TRIFLUOROETHYLATION; LATE-STAGE FLUORINATION; HYPERVALENT IODINE; TRIFLUOROMETHYLATION; FUNCTIONALIZATION; DIFLUOROALKENES; HETEROARENES; ANNULATION; NITRILES; IODIDES;

D O I：

10.1016/j.cclet.2021.09.004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we report a simple and efficient method for the direct installation of chlorodifluoroethyl group onto aromatic molecules of various aromatic amides with a new 2-chloro,2,2-difluoroethyl(mesityl)iodonium salt (CDFI). Moreover, the chlorodifluoroethyl compounds could be smoothly converted into difluorovinyl compounds in a one-pot or discrete procedure and regarded as a steady source of difluorovinyl compounds with "HCl-mask". (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

引用

页码：1541 / 1544

页数：4

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