Molecular Interaction, Antimicrobial, Antioxidant, Cytotoxic and Magnetic Properties of Mn12 Benzoate

The synthesis, crystal structure, antimicrobial activity, cytotoxic effect on root tip of Allium cepa Linn (A. cepa L.), antioxidant and magnetochemical properties of [Mn12O12(PhCO2)(16)(CH3OH)(4)]center dot 3CH(3)CN (1) cluster and its molecular interaction with Rhodamine B (RhB) are reported herein. The degree of molecular interaction of RhB with Mn-12 benzoate radically changed with time. The absorption peak of Rh B at 554 nm disappeared with addition of solid Mn-12 benzoate and a new peak appeared at 497 nm, which indicated a possible molecular interaction between Mn-12 benzoate and RhB. Mn-12 benzoate significantly inhibited the maximum growth of Enterococcus faecalis MCC 2041(T) with a value of inhibition zone of 14.00 +/- 0.76, compared to other bacteria. The MIC and MBC of the test sample against the sensitive bacterial strains was in the range of 30-10 mg/mL and 40-10 mg/mL, respectively; whereas the parental compound did not show any zone of inhibition. The cytotoxicity and DNA damage study in root tip cells of A. cepa L. demonstrated very promising result in presence of Mn-12 benzoate. The antioxidant activity of Mn-12 benzoate was assessed by 2, 2 '-diphenyl-1-picryl hydrazyl radical (DPPH center dot) assay and the free radical scavenging activity was found to be 68.8%. Variable-temperature (T) and -field (H) solid-state dielectric current (dc) and alternative current (ac) magnetic susceptibility measurements were done on complex 1 over 1.8-300 K, which exhibited ground state spins of S = 10. Graphic