The role of TALL-1 and APRIL in immune regulation

被引：27

作者：

Khare, SD

Hsu, HL

机构：

[1] Amgen Inc, Dept Pathol Pharmacol, Thousand Oaks, CA 91320 USA

[2] Amgen Inc, Dept Inflammat, Thousand Oaks, CA 91320 USA

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 02期

关键词：

D O I：

10.1016/S1471-4906(00)01843-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Members of the tumor necrosis factor (TNF) superfamily play important roles in cell proliferation and death during immune regulation. Most members are synthesized as type II transmembrane proteins; the carboxy terminal extracellular domain can be cleaved from the cell membrane to form soluble active cytokines that bind to appropriate members of the TNF receptor family Here, we describe the biological significance of recently discovered members of the TNF superfamily (TALL-1 and APRIL) and their receptors (TACI and BCMA) in the pathophysiology of human diseases.

引用

页码：61 / 63

页数：3

共 20 条

[1]

BATTEN M, IN PRESS J EXP MED

[2] BCMAP - AN INTEGRAL MEMBRANE-PROTEIN IN THE GOLGI-APPARATUS OF HUMAN MATURE B-LYMPHOCYTES [J].

GRAS, MP ;

LAABI, Y ;

LINARESCRUZ, G ;

BLONDEL, MO ;

RIGAUT, JP ;

BROUET, JC ;

LECA, G ;

HAGUENAUERTSAPIS, R ;

TSAPIS, A .

INTERNATIONAL IMMUNOLOGY, 1995, 7 (07) :1093-1106

[3] CD40 and CD154 in cell-mediated immunity [J].

Grewal, IS ;

Flavell, RA .

ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :111-135

[4] TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease [J].

Gross, JA ;

Johnston, J ;

Mudri, S ;

Enselman, R ;

Dillon, SR ;

Madden, K ;

Xu, WF ;

Parrish-Novak, J ;

Foster, D ;

Lofton-Day, C ;

Moore, M ;

Littau, A ;

Grossman, A ;

Haugen, H ;

Foley, K ;

Blumberg, H ;

Harrison, K ;

Kindsvogel, W ;

Clegg, CH .

NATURE, 2000, 404 (6781) :995-999

[5] Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice [J].

Khare, SD ;

Sarosi, I ;

Xia, XZ ;

McCabe, S ;

Miner, K ;

Solovyev, I ;

Hawkins, N ;

Kelley, M ;

Chang, D ;

Van, G ;

Ross, L ;

Delaney, J ;

Wang, L ;

Lacey, D ;

Boyle, WJ ;

Hsu, HL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) :3370-3375

[6] THE BCMA GENE, PREFERENTIALLY EXPRESSED DURING B-LYMPHOID MATURATION, IS BIDIRECTIONALLY TRANSCRIBED [J].

LAABI, Y ;

GRAS, MP ;

BROUET, JC ;

BERGER, R ;

LARSEN, CJ ;

TSAPIS, A .

NUCLEIC ACIDS RESEARCH, 1994, 22 (07) :1147-1154

[7] Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations [J].

Mackay, F ;

Woodcock, SA ;

Lawton, P ;

Ambrose, C ;

Baetscher, M ;

Schneider, P ;

Tschopp, J ;

Browning, JL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (11) :1697-1710

[8] The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily [J].

Madry, C ;

Laabi, Y ;

Callebaut, I ;

Roussel, J ;

Hatzoglou, A ;

Le Coniat, M ;

Mornon, JP ;

Berger, R ;

Tsapis, A .

INTERNATIONAL IMMUNOLOGY, 1998, 10 (11) :1693-1702

[9] Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI [J].

Marsters, SA ;

Yan, MH ;

Pitti, RM ;

Haas, PE ;

Dixit, VM ;

Ashkenazi, A .

CURRENT BIOLOGY, 2000, 10 (13) :785-788

[10] BLyS: Member of the tumor necrosis factor family and B lymphocyte stimulator [J].

Moore, PA ;

Belvedere, O ;

Orr, A ;

Pieri, K ;

LaFleur, DW ;

Feng, P ;

Soppet, D ;

Charters, M ;

Gentz, R ;

Parmelee, D ;

Li, YL ;

Galperina, O ;

Giri, J ;

Roschke, V ;

Nardelli, B ;

Carrell, J ;

Sosnovtseva, S ;

Greenfield, W ;

Ruben, SM ;

Olsen, HS ;

Fikes, J ;

Hilbert, DM .

SCIENCE, 1999, 285 (5425) :260-263

← 1 2 →