Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus

被引：9

作者：

Chen, Jiancheng ^{[1
]}

Yamada, Shuhei ^{[1
]}

Hama, Yoshiki ^{[1
]}

Shetty, Ajaya Kumar ^{[1
]}

Kobayashi, Takanari ^{[1
]}

Oda, Hiroshi ^{[2
]}

Seiki, Kosuke ^{[2
]}

Kim, Eunmi ^{[3
]}

Kimura, Takashi ^{[3
]}

Takahashi, Naonori ^{[4
,5
]}

Hidari, Kazuya I. P. J. ^{[4
,5
]}

Suzuki, Takashi ^{[4
,5
]}

Suzuki, Yasuo ^{[6
]}

Sugahara, Kazuyuki ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Life Sci, Frontier Res Ctr Postgenom Sci & Technol, Lab Proteoglycan Signaling & Therapeut,Kita Ku, Sapporo, Hokkaido 0010021, Japan

[2] Maruha Nichiro Holdings Inc, Cent Res Inst, Ibaraki 3004295, Japan

[3] Hokkaido Univ, Res Ctr Zoonosis Control, Dept Mol Pathobiol, Sapporo, Hokkaido 0010020, Japan

[4] Univ Shizuoka, Sch Pharmaceut Sci, Dept Biochem, Shizuoka 4228526, Japan

[5] Univ Shizuoka, Global COE Program Innovat Human Hlth Sci, Shizuoka 4228526, Japan

[6] Chubu Univ, Coll Life & Hlth Sci, Dept Biochem Sci, Aichi 4878501, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2011年 / 412卷 / 01期

关键词：

Glycosaminoglycans; Heparan sulfate; Dengue virus; Japanese encephalitis virus; Anticoagulant activity; HERPES-SIMPLEX-VIRUS; BINDING; PROTEOGLYCANS; GROWTH; OLIGOSACCHARIDES; GLYCOSAMINOGLYCANS; BRAIN; CELLS; ENTRY;

D O I：

10.1016/j.bbrc.2011.07.059

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure and biological activities of a highly sulfated heparan sulfate (HS) extracted from shrimp (Penaeus brasiliensis) heads were characterized. Structurally the shrimp HS was more heterogenous than heparin, although it is still highly sulfated. The molecular mass of the shrimp HS preparation was determined to be 32.3 kDa by gel filtration HPLC. Analysis by surface plasmon resonance demonstrated that various growth/differentiation factors specifically bound to the shrimp HS with comparable affinity. Notably, the shrimp HS had a greater inhibitory effect against infections by dengue virus type 2 as well as Japanese encephalitis virus than heparin. Experiments on anticoagulant activity indicated that the shrimp HS exhibited significant anti-thrombin activity, but less than the commercial heparin. Hence, the HS preparation from shrimp heads, an industrial waste, is a prospective agent for a variety of clinical applications. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：136 / 142

页数：7

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