Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus

被引:9
作者
Chen, Jiancheng [1 ]
Yamada, Shuhei [1 ]
Hama, Yoshiki [1 ]
Shetty, Ajaya Kumar [1 ]
Kobayashi, Takanari [1 ]
Oda, Hiroshi [2 ]
Seiki, Kosuke [2 ]
Kim, Eunmi [3 ]
Kimura, Takashi [3 ]
Takahashi, Naonori [4 ,5 ]
Hidari, Kazuya I. P. J. [4 ,5 ]
Suzuki, Takashi [4 ,5 ]
Suzuki, Yasuo [6 ]
Sugahara, Kazuyuki [1 ]
机构
[1] Hokkaido Univ, Grad Sch Life Sci, Frontier Res Ctr Postgenom Sci & Technol, Lab Proteoglycan Signaling & Therapeut,Kita Ku, Sapporo, Hokkaido 0010021, Japan
[2] Maruha Nichiro Holdings Inc, Cent Res Inst, Ibaraki 3004295, Japan
[3] Hokkaido Univ, Res Ctr Zoonosis Control, Dept Mol Pathobiol, Sapporo, Hokkaido 0010020, Japan
[4] Univ Shizuoka, Sch Pharmaceut Sci, Dept Biochem, Shizuoka 4228526, Japan
[5] Univ Shizuoka, Global COE Program Innovat Human Hlth Sci, Shizuoka 4228526, Japan
[6] Chubu Univ, Coll Life & Hlth Sci, Dept Biochem Sci, Aichi 4878501, Japan
关键词
Glycosaminoglycans; Heparan sulfate; Dengue virus; Japanese encephalitis virus; Anticoagulant activity; HERPES-SIMPLEX-VIRUS; BINDING; PROTEOGLYCANS; GROWTH; OLIGOSACCHARIDES; GLYCOSAMINOGLYCANS; BRAIN; CELLS; ENTRY;
D O I
10.1016/j.bbrc.2011.07.059
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The structure and biological activities of a highly sulfated heparan sulfate (HS) extracted from shrimp (Penaeus brasiliensis) heads were characterized. Structurally the shrimp HS was more heterogenous than heparin, although it is still highly sulfated. The molecular mass of the shrimp HS preparation was determined to be 32.3 kDa by gel filtration HPLC. Analysis by surface plasmon resonance demonstrated that various growth/differentiation factors specifically bound to the shrimp HS with comparable affinity. Notably, the shrimp HS had a greater inhibitory effect against infections by dengue virus type 2 as well as Japanese encephalitis virus than heparin. Experiments on anticoagulant activity indicated that the shrimp HS exhibited significant anti-thrombin activity, but less than the commercial heparin. Hence, the HS preparation from shrimp heads, an industrial waste, is a prospective agent for a variety of clinical applications. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:136 / 142
页数:7
相关论文
共 36 条
[1]   Identification and characterization of carbohydrate molecules in mammalian cells recognized by dengue virus type 2 [J].
Aoki, C ;
Hidari, KIPJ ;
Itonori, S ;
Yamada, A ;
Takahashi, N ;
Kasama, T ;
Hasebe, F ;
Islam, MA ;
Hatano, K ;
Matsuoka, K ;
Taki, T ;
Guo, CT ;
Takahashi, T ;
Sakano, Y ;
Suzuki, T ;
Miyamoto, D ;
Sugita, M ;
Terunuma, D ;
Morita, K ;
Suzuki, Y .
JOURNAL OF BIOCHEMISTRY, 2006, 139 (03) :607-614
[2]   EVALUATION OF CRITICAL GROUPS REQUIRED FOR THE BINDING OF HEPARIN TO ANTITHROMBIN [J].
ATHA, DH ;
STEPHENS, AW ;
ROSENBERG, RD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (04) :1030-1034
[3]   Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfate [J].
Barth, H ;
Schäfer, C ;
Adah, MI ;
Zhang, FM ;
Linhardt, RJ ;
Toyoda, H ;
Kinoshita-Toyoda, A ;
Toida, T ;
van Kuppevelt, TH ;
Depla, E ;
von Weizsäcker, F ;
Blum, HE ;
Baumert, TF .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (42) :41003-41012
[4]   Functions of cell surface heparan sulfate proteoglycans [J].
Bernfield, M ;
Götte, M ;
Park, PW ;
Reizes, O ;
Fitzgerald, ML ;
Lincecum, J ;
Zako, M .
ANNUAL REVIEW OF BIOCHEMISTRY, 1999, 68 :729-777
[5]   Heparan sulphate proteoglycans fine-tune mammalian physiology [J].
Bishop, Joseph R. ;
Schuksz, Manuela ;
Esko, Jeffrey D. .
NATURE, 2007, 446 (7139) :1030-1037
[6]   Outbreak of Adverse Reactions Associated with Contaminated Heparin [J].
Blossom, David B. ;
Kallen, Alexander J. ;
Patel, Priti R. ;
Elward, Alexis ;
Robinson, Luke ;
Gao, Ganpan ;
Langer, Robert ;
Perkins, Kiran M. ;
Jaeger, Jennifer L. ;
Kurkjian, Katie M. ;
Jones, Marilyn ;
Schillie, Sarah F. ;
Shehab, Nadine ;
Ketterer, Daniel ;
Venkataraman, Ganesh ;
Kishimoto, Takashi Kei ;
Shriver, Zachary ;
McMahon, Ann W. ;
Austen, K. Frank ;
Kozlowski, Steven ;
Srinivasan, Arjun ;
Turabelidze, George ;
Gould, Carolyn V. ;
Arduino, Matthew J. ;
Sasisekharan, Ram .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (25) :2674-2684
[7]   MICRODETERMINATION OF PROTEOGLYCANS AND GLYCOSAMINOGLYCANS IN THE PRESENCE OF GUANIDINE-HYDROCHLORIDE [J].
CHANDRASEKHAR, S ;
ESTERMAN, MA ;
HOFFMAN, HA .
ANALYTICAL BIOCHEMISTRY, 1987, 161 (01) :103-108
[8]   Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate [J].
Chen, YP ;
Maguire, T ;
Hileman, RE ;
Fromm, JR ;
Esko, JD ;
Linhardt, RJ ;
Marks, RM .
NATURE MEDICINE, 1997, 3 (08) :866-871
[9]   Using a 3-O-sulfated heparin octasaccharide to inhibit the entry of herpes simplex virus type 1 [J].
Copeland, Ronald ;
Balasubramaniam, Arun ;
Tiwari, Vaibhav ;
Zhang, Fuming ;
Bridges, Arlene ;
Linhardt, Robert J. ;
Shukla, Deepak ;
Liu, Jian .
BIOCHEMISTRY, 2008, 47 (21) :5774-5783
[10]   Specific molecular interactions of oversulfated chondroitin sulfate E with various heparin-binding growth factors - Implications as a physiological binding partner in the brain and other tissues [J].
Deepa, SS ;
Umehara, Y ;
Higashiyama, S ;
Itoh, N ;
Sugahara, K .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (46) :43707-43716