The association between semaphorin 3A levels and gluten-free diet in patients with celiac disease

被引：3

作者：

Kessel, Aharon ^{[1
]}

Lin, Chen ^{[1
]}

Vadasz, Zahava ^{[1
]}

Peri, Regina ^{[1
]}

Eiza, Nasren ^{[1
]}

Berkowitz, Drora ^{[2
]}

机构：

[1] Technion Fac Med, Div Allergy & Clin Immunol, Bnai Zion Med Ctr, Haifa, Israel

[2] Technion, Div Pediat Gastroenterol, Bnai Zion Med Ctr, Fac Med, Haifa, Israel

来源：

CLINICAL IMMUNOLOGY | 2017年 / 184卷

关键词：

Celiac disease; Semaphorin; 3A; T regulatory cells; Gluten free diet; REGULATORY T-CELLS; ANTIGEN-PRESENTING CELLS; DENDRITIC CELLS; NEUROPILIN-1; GROWTH; REORGANIZATION; AUTOIMMUNITY; CYTOSKELETON; INHIBITION; RECEPTORS;

D O I：

10.1016/j.clim.2017.05.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Celiac disease (CD) is an inflammatory disease affecting the small intestine. We aim to assess serum level and expression of semaphorin 3A (Sema3A) on T regulatory (Treg) cells in CD patients. Twenty-six newly diagnosed celiac patients, 13 celiac patients on a gluten-free diet and 16 healthy controls included in the study. Sema3A protein level in the serum of celiac patients was significantly higher compared to healthy group (7.17 +/- 1.8 ng/ml vs. 5.67 +/- 1.5 ng/ml, p = 0.012). Sema3A expression on Treg cells was statistically lower in celiac patients compared to healthy subjects (p = 0.009) and significantly lower in celiac patients compared to celiac patients on gluten free diet (p = 0.04). Negative correlation was found between Sema3A on Teg cells and the level of IgA anti-tTG antibodies (r = -0346, p < 0.01) and anti-DGP (r = -0.448, p < 0.01). This study suggests involvement of the Sema3A in the pathogenesis of CD. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：73 / 76

页数：4

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