Human leukocyte antigen epitope analysis to assess complement- and non-complement-binding donor-specific antibody repertoire in a pediatric heart transplant recipient

被引：26

作者：

Zeevi, Adriana ^{[1
]}

Marrari, Marilyn ^{[1
]}

Feingold, Brian ^{[1
,2
]}

Webber, Steven ^{[1
,2
]}

Duquesnoy, Rene J. ^{[1
]}

机构：

[1] Univ Pittsburgh, Med Ctr, Pittsburgh, PA 15213 USA

[2] UPMC, Childrens Hosp Pittsburgh, Pittsburgh, PA 15224 USA

来源：

HUMAN IMMUNOLOGY | 2012年 / 73卷 / 01期

关键词：

Pediatric heart transplant; HLA antibody; HLA epitope; C1q binding; HLAMatchmaker; Antibody-mediated rejection (AMR); Transplant (Tx); Donor-specific antibody (DSA); Luminex IgG (L-IgG); Luminex C1q (L-C1q); Mean fluorescence intensity (MFI); ORGAN-TRANSPLANTATION;

D O I：

10.1016/j.humimm.2011.10.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This case report summarizes the spectrum of anti-human leukocyte antigen (HLA) antibody reactivity determined by single-allele Luminex immunoglobulin G and C1q binding assays before transplant, during an episode of antibody-mediated rejection (AMR), and following treatment in a sensitized pediatric heart transplant (Tx) recipient. We were able to discriminate between complement- and non-complement-binding epitope-specific antibodies present against a single donor antigen (HLA-A2) during the progression of AMR and its resolution. Our findings illustrate the usefulness of determining antibody specificities against epitopes using various Luminex-based assays. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：48 / 51

页数：4

共 3 条

[1] Rapid Reduction in Donor-Specific Anti-Human Leukocyte Antigen Antibodies and Reversal of Antibody-Mediated Rejection With Bortezomib in Pediatric Heart Transplant Patients
Morrow, William Robert
Frazier, Elizabeth A.
Mahle, William T.
Harville, Terry O.
Pye, Sherry E.
Knecht, Kenneth R.
Howard, Emily L.
Smith, R. Neal
Saylors, Robert L.
Garcia, Xiomara
Jaquiss, Robert D. B.
Woodle, E. Steve
TRANSPLANTATION, 2012, 93 (03) : 319 - 324
[2] Class II Human Leukocyte Antigen Epitope Mismatch Predicts De Novo Donor-Specific Antibody Formation After Liver Transplantation
Kubal, Chandrashekhar A.
Mangus, Richard
Ekser, Burcin
Mihaylov, Plamen
Ceballos, Brian
Higgins, Nancy
Chalasani, Naga
Ghabril, Marwan
Nephew, Lauren
Lobashevsky, Andrew
LIVER TRANSPLANTATION, 2018, 24 (08) : 1101 - 1108
[3] Case Report: Binding of a Clinically Relevant Human Leukocyte Antigen-DQα-Specific Antibody in a Kidney Graft Recipient is Inhibited by Donor-Type Human Leukocyte Antigen-DQβ Chain
Mikkelsen, S.
Korsholm, T.
Iburg, A.
Petersen, M. S.
Moller, B. K.
TRANSPLANTATION PROCEEDINGS, 2013, 45 (03) : 1209 - 1212

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