Natural Killer Cells and Current Applications of Chimeric Antigen Receptor-Modified NK-92 Cells in Tumor Immunotherapy

被引：109
作者：
Zhang, Jianguang [1 ]
Zheng, Huifang [1 ]
Diao, Yong [1 ]
机构：
[1] Huaqiao Univ, Sch Med, Quanzhou 362021, Fujian, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 02期
基金：
中国国家自然科学基金;
关键词：
natural killer cell line; NK-92; chimeric antigen receptor; immunotherapy; tumor; NK CELLS; T-CELLS; CANCER-CELLS; LINE NK-92; CELLULAR IMMUNOTHERAPY; ADOPTIVE IMMUNOTHERAPY; CYTOTOXIC ACTIVITY; CLINICAL-TRIAL; 2B4; CD244; LEUKEMIA;
D O I：
10.3390/ijms20020317
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Natural killer (NK) cells are innate immune cells that can be activated rapidly to target abnormal and virus-infected cells without prior sensitization. With significant advancements in cell biology technologies, many NK cell lines have been established. Among these cell lines, NK-92 cells are not only the most widely used but have also been approved for clinical applications. Additionally, chimeric antigen receptor-modified NK-92 cells (CAR-NK-92 cells) have shown strong antitumor effects. In this review, we summarize established human NK cell lines and their biological characteristics, and highlight the applications of NK-92 cells and CAR-NK-92 cells in tumor immunotherapy.
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页数：20
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