Structural study of the copper(II)-enrofloxacin metallo-antibiotic

被引：20

作者：

Ftouni, Hussein ^{[1
]}

Sayen, Stephanie ^{[1
]}

Boudesocque, Stephanie ^{[1
]}

Dechamps-Olivier, Isabelle ^{[1
]}

Guillon, Emmanuel ^{[1
]}

机构：

[1] Univ Reims, ICMR, CNRS, UMR 6229,Fac Sci, F-51687 Reims 2, France

来源：

INORGANICA CHIMICA ACTA | 2012年 / 382卷

关键词：

Copper; Antibiotic; Enrofloxacin; Complex; EXAFS; XANES; ANTIBACTERIAL ACTIVITY; SUPEROXIDE-DISMUTASE; COPPER(II) COMPLEX; CRYSTAL-STRUCTURES; ABSORPTION; 1,10-PHENANTHROLINE; FLUOROQUINOLONES; CIPROFLOXACIN; ENROFLOXACIN; NI(II);

D O I：

10.1016/j.ica.2011.12.012

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The structure of [Cu(erx)(2)(H2O)(2)] complex was assessed using copper K-edge X-ray absorption spectroscopy (XAS) through X-ray absorption near edge structure (XANES) and extended X-ray absorption fine structure (EXAFS) combined with EPR spectroscopy. A Jahn-Teller distorted octahedra was evidenced for Cu2+ geometry. Four equatorial oxygen atoms from two enrofloxacin ligands were found with Cu-O-eq distances of 1.93 angstrom (+/- 0.02). The coordination was completed by two water molecules in axial position at an average distance of 2.11 angstrom (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：186 / 190

页数：5

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