Asthma in the elderly: Current understanding and future research needs-a report of a National Institute on Aging (NIA) workshop

被引：185

作者：

Hanania, Nicola A. ^{[1
]}

King, Monroe J. ^{[2
]}

Braman, Sidney S. ^{[3
]}

Saltoun, Carol ^{[4
]}

Wise, Robert A. ^{[5
]}

Enright, Paul ^{[6
]}

Falsey, Ann R. ^{[7
]}

Mathur, Sameer K. ^{[8
]}

Ramsdell, Joe W. ^{[9
]}

Rogers, Linda ^{[10
]}

Stempel, David A. ^{[11
]}

Lima, John J. ^{[12
]}

Fish, James E. ^{[13
]}

Wilson, Sandra R. ^{[14
]}

Boyd, Cynthia ^{[5
]}

Patel, Kushang V. ^{[15
]}

Irvin, Charles G. ^{[17
]}

Yawn, Barbara P. ^{[16
]}

Halm, Ethan A. ^{[18
]}

Wasserman, Stephen I. ^{[9
]}

Sands, Mark F. ^{[19
]}

Ershler, William B. ^{[20
]}

Ledford, Dennis K. ^{[2
]}

机构：

[1] Baylor Coll Med, Sect Pulm & Crit Care Med, Asthma Clin Res Ctr, Houston, TX 77030 USA

[2] Univ S Florida, Div Allergy & Immunol, Dept Med, Tampa, FL USA

[3] Brown Univ, Providence, RI 02912 USA

[4] Northwestern Univ, Chicago, IL 60611 USA

[5] Johns Hopkins Univ, Baltimore, MD USA

[6] Univ Arizona, Tucson, AZ USA

[7] Univ Rochester, Rochester, NY 14627 USA

[8] Univ Wisconsin, Dept Med, Sect Allergy Pulm & Crit Care, Madison, WI 53706 USA

[9] Univ Calif San Diego, San Diego, CA 92103 USA

[10] NYU, Sch Med, New York, NY USA

[11] GlaxoSmithKline, Bellevue, WA USA

[12] Nemours Children Clin, Jacksonville, FL USA

[13] Genentech Inc, Gladwyne, England

[14] Stanford Univ, Sch Med, Palo Alto, CA 94304 USA

[15] NIA, Bethesda, MD 20892 USA

[16] Univ Minnesota, Dept Family & Community Hlth, Rochester, MN USA

[17] Univ Vermont, Burlington, VT 05405 USA

[18] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA

[19] SUNY Buffalo, Dept Veteran Affairs, Med Ctr, Buffalo, NY 14260 USA

[20] Inst Adv Studies Aging, Gaithersburg, MD USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2011年 / 128卷 / 03期

基金：

美国医疗保健研究与质量局;

关键词：

Aging; airway; allergy; asthma; elderly; immune mechanisms; immunosenescence; QUALITY-OF-LIFE; EXHALED NITRIC-OXIDE; OBSTRUCTIVE PULMONARY-DISEASE; RESPIRATORY-TRACT INFECTION; SYNCYTIAL VIRUS-INFECTION; LOWER-EXTREMITY FUNCTION; HEALTH-CARE UTILIZATION; IMMUNOGLOBULIN-E LEVELS; AIR-FLOW OBSTRUCTION; SKIN-TEST REACTIVITY;

D O I：

10.1016/j.jaci.2011.06.048

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Asthma in the elderly is underdiagnosed and undertreated, and there is a paucity of knowledge on the subject. The National Institute on Aging convened this workshop to identify what is known and what gaps in knowledge remain and suggest research directions needed to improve the understanding and care of asthma in the elderly. Asthma presenting at an advanced age often has similar clinical and physiologic consequences as seen with younger patients, but comorbid illnesses and the psychosocial effects of aging might affect the diagnosis, clinical presentation, and care of asthma in this population. At least 2 phenotypes exist among elderly patients with asthma; those with longstanding asthma have more severe airflow limitation and less complete reversibility than those with late-onset asthma. Many challenges exist in the recognition and treatment of asthma in the elderly. Furthermore, the pathophysiologic mechanisms of asthma in the elderly are likely to be different from those seen in young asthmatic patients, and these differences might influence the clinical course and outcomes of asthma in this population. (J Allergy Clin Immunol 2011;128:S4-24.)

引用

页码：S4 / S24

页数：21

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