Estimation of the bivariate distribution function for censored gap times

被引:1
|
作者
Moreira, Ana [1 ,2 ]
Araujo, Artur
Meira-Machado, Luis
机构
[1] Univ Minho, Ctr Math, Campus Azurem, P-4800058 Guimaraes, Portugal
[2] Univ Minho, Dept Math & Applicat, Campus Azurem, P-4800058 Guimaraes, Portugal
关键词
Gap times; Kaplan-Meier; Multi-state model; Nonparametric estimation; Simulation study; NONPARAMETRIC-ESTIMATION;
D O I
10.1080/03610918.2014.963609
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
In many medical studies, patients may experience several events during follow-up. The times between consecutive events (gap times) are often of interest and lead to problems that have received much attention recently. In this work, we consider the estimation of the bivariate distribution function for censored gap times. Some related problems such as the estimation of the marginal distribution of the second gap time and the conditional distribution are also discussed. In this article, we introduce a nonparametric estimator of the bivariate distribution function based on Bayes' theorem and Kaplan-Meier survival function and explore the behavior of the four estimators through simulations. Real data illustration is included.
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页码:275 / 300
页数:26
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