Renal transplantation experience in a patient with factor V Leiden homozygous, MTHFR C677T heterozygous, and PAI heterozygous mutation

被引:0
|
作者
Gulhan, Bora [1 ]
Tavil, Betul [2 ]
Gumruk, Fatma [2 ]
Aki, Tuncay F. [3 ]
Topaloglu, Rezan [1 ]
机构
[1] Hacettepe Univ, Dept Pediat Nephrol, Fac Med, TR-06100 Ankara, Turkey
[2] Hacettepe Univ, Dept Pediat Hematol, Fac Med, TR-06100 Ankara, Turkey
[3] Hacettepe Univ, Dept Urol, Fac Med, TR-06100 Ankara, Turkey
关键词
factor V Leiden; thrombophilia; renal transplantation; CHRONIC ALLOGRAFT NEPHROPATHY; INHERITED THROMBOPHILIA; KIDNEY-TRANSPLANTATION; GRAFT DYSFUNCTION; ACUTE REJECTION; RISK; ASSOCIATION; THROMBOSIS; POLYMORPHISMS;
D O I
10.1111/petr.12526
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Vascular complications are important causes of allograft loss in renal transplantation. A two and a half-month-old boy was diagnosed with posterior urethral valve and progressed to end-stage renal disease at eightyr of age. During the HD period, a central venous catheter was replaced three times for repeated thrombosis. The boy was found to be homozygous for FVL and heterozygous for both MTHFR (C677T) and PAI. At the age of 12, renal transplantation was performed from a deceased donor. Postoperative anticoagulation therapy was initiated with continuous intravenous administration of heparin at the dose of 10IU/kg/h. HD was performed for the first threedays. By the fourth day of transplantation, his urine output had increased gradually. Heparin infusion was continued for 18days during hospitalization at the same dosage. Thereafter, he was discharged with LMWH. On the third month after transplantation, his serum creatinine level was 1.1mg/dL and eGFR was 75.7mL/min/1.73m(2). He has still been using LMWH, and his eGFR was 78.7mL/min/1.73m(2) eightmonths after transplantation. Postoperative low-dose heparin treatment is a safe strategy for managing a patient with multiple thrombotic risk factors.
引用
收藏
页码:E126 / E129
页数:4
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